恶性胸膜间皮瘤中基因-干性-分泌组的相互作用：分子动力学与临床提示

The Genes-Stemness-Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints.

作者信息

Stella Giulia M, Marchiò Caterina, Bari Elia, Ferrarotti Ilaria, Bertuccio Francesco R, Di Gennaro Antonella, Abbott David Michael, Putignano Paola, Campo Ilaria, Torre Maria Luisa, Corsico Angelo G

机构信息

Department of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, 27100 Pavia, Italy.

Unit of Respiratory Diseases, Cardiothoracic and Vascular Department, IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

出版信息

Int J Mol Sci. 2023 Feb 9;24(4):3496. doi: 10.3390/ijms24043496.

DOI:10.3390/ijms24043496

PMID:36834912

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9963101/

Abstract

MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from the exceptional crosstalk between neoplastic cells and matrix components, among which one main area of focus is hypoxia. Here we discuss the novel therapeutic strategies focused on the exploitation of MPM genetic asset and its interconnection with the surrounding hypoxic microenvironment as well as transcript products and microvesicles representing both an insight into the pathogenesis and promising actionable targets.

摘要

恶性胸膜间皮瘤具有独特的、较差的体细胞突变格局，主要由环境选择压力驱动。这一特征极大地限制了有效治疗方法的开发。然而，已知基因组事件与恶性胸膜间皮瘤的进展相关，并且特定的基因特征源自肿瘤细胞与基质成分之间特殊的相互作用，其中一个主要关注领域是缺氧。在此，我们讨论了新的治疗策略，这些策略专注于利用恶性胸膜间皮瘤的遗传特性及其与周围缺氧微环境的相互联系，以及转录产物和微泡，它们既有助于深入了解发病机制，也是有前景的可操作靶点。