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与怀孕期间室外和室内空气污染损害相关的细胞机制。

Cellular mechanisms linking to outdoor and indoor air pollution damage during pregnancy.

机构信息

Cellular Signaling and Differentiation Laboratory (CSDL), School of Medical Technology, Faculty of Medicine and Science, Universidad San Sebastián, Santiago, Chile.

Department of Chemical and Bioprocess Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile.

出版信息

Front Endocrinol (Lausanne). 2023 Feb 15;14:1084986. doi: 10.3389/fendo.2023.1084986. eCollection 2023.

Abstract

Pregnancies are a critical window period for environmental influences over the mother and the offspring. There is a growing body of evidence associating indoor and outdoor air pollution exposure to adverse pregnancy outcomes such as preterm birth and hypertensive disorders of pregnancy. Particulate matter (PM) could trigger oxi-inflammation and could also reach the placenta leading to placental damage with fetal consequences. The combination of strategies such as risk assessment, advise about risks of environmental exposures to pregnant women, together with nutritional strategies and digital solutions to monitor air quality can be effective in mitigating the effects of air pollution during pregnancy.

摘要

妊娠是母亲和胎儿受到环境影响的关键窗口期。越来越多的证据表明,室内和室外空气污染暴露与不良妊娠结局有关,如早产和妊娠高血压疾病。颗粒物(PM)可引发氧化炎症,也可到达胎盘,导致胎盘损伤,进而对胎儿产生影响。通过风险评估、向孕妇提供有关环境暴露风险的建议、营养策略以及监测空气质量的数字解决方案等策略的结合,可以有效减轻怀孕期间空气污染的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/518c/9974835/1af11df12cd4/fendo-14-1084986-g001.jpg

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