Cell-Free Supernatant Improves Glucose and Lipid Metabolisms in .

To explore the mechanism by which cell-free supernatant improves glucose and lipid metabolisms in , the present study used different dilution concentrations of cell-free supernatant as an intervention for with under a high-glucose diet. The changes in lifespan, exercise ability, level of free radicals, and characteristic indexes of glucose and lipid metabolisms were studied. Furthermore, the expression of key genes of glucose and lipid metabolisms was detected by qRT-PCR. The results showed that cell-free supernatant significantly improved the movement ability, prolonged the lifespan, reduced the level of ROS, and alleviated oxidative damage in . cell-free supernatant supported resistance to increases in glucose and triglyceride induced by a high-glucose diet and downregulated the expression of key genes of glucose metabolism, such as , , , and while upregulating the expression of key genes of lipid metabolism, such as , , , and as well as down-regulating the expression of the gene to inhibit fatty acid biosynthesis. These findings indicated that cell-free supernatant, as a postbiotic, has the potential to prevent obesity and improve glucose metabolism disorders and other diseases.