肿瘤周围微环境：物理学与免疫学。
The peritumor microenvironment: physics and immunity.
机构信息
Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, USA.
出版信息
Trends Cancer. 2023 Aug;9(8):609-623. doi: 10.1016/j.trecan.2023.04.004. Epub 2023 May 6.
Abstract
Cancer initiation and progression drastically alter the microenvironment at the interface between healthy and malignant tissue. This site, termed the peritumor, bears unique physical and immune attributes that together further promote tumor progression through interconnected mechanical signaling and immune activity. In this review, we describe the distinct physical features of the peritumoral microenvironment and link their relationship to immune responses. The peritumor is a region rich in biomarkers and therapeutic targets and thus is a key focus for future cancer research as well as clinical outlooks, particularly to understand and overcome novel mechanisms of immunotherapy resistance.
摘要
癌症的发生和发展会极大地改变健康组织与恶性组织交界处的微环境。这个部位被称为肿瘤周围组织，具有独特的物理和免疫属性，这些属性通过相互关联的机械信号和免疫活性进一步促进肿瘤的进展。在这篇综述中，我们描述了肿瘤周围微环境的独特物理特征，并将其与免疫反应联系起来。肿瘤周围组织是富含生物标志物和治疗靶点的区域，因此是未来癌症研究以及临床展望的一个关键焦点，特别是为了理解和克服免疫治疗耐药的新机制。
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