血根碱，类似于大观霉素的 MIC，体外显示出良好的抗淋病奈瑟菌活性。

Sanguinarine, similar to the MICs of spectinomycin, exhibits good anti-Neisseria gonorrhoeae activity in vitro.

机构信息

Institute of Dermatology, Guangzhou Medical University, Guangzhou, 510095, PR China; Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, 510095, PR China.

Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, 510095, PR China.

出版信息

J Infect Chemother. 2023 Sep;29(9):927-929. doi: 10.1016/j.jiac.2023.05.022. Epub 2023 Jun 7.

DOI:10.1016/j.jiac.2023.05.022

PMID:37295648

Abstract

The increasing antibiotic resistance of Neisseria gonorrhoeae (NG) is an urgent need to explore new and effective drugs. The antibacterial activities of spectinomycin and sanguinarine against 117 clinical NG isolates and time-kill curve of sanguinarine were evaluated. Almost all isolates were resistant to penicillin (91.5%) and ciprofloxacin (96.5%), 8.5% showed resistance to azithromycin, 10.3% and 10.3% had decreased susceptibility/resistance to ceftriaxone and cefixime, respectively, whereas 100% were susceptible to spectinomycin. The minimum inhibitory concentration (MIC) ranges, MIC, MIC and MIC values of sanguinarine were 2-64 μg/ml, 16 μg/ml, 32 μg/ml and 16.9 μg/ml, respectively, and time-kill curve showed killing of bacteria in a dose-dependent manner during the assay time of 6h, very similar to spectinomycin. Sanguinarine has great potential as an effective and novel anti-NG agent.

摘要

淋病奈瑟菌（NG）的抗生素耐药性不断增加，因此迫切需要探索新的有效药物。本研究评估了大观霉素和血根碱对 117 株临床淋病奈瑟菌分离株的抗菌活性和时间杀伤曲线。几乎所有分离株对青霉素（91.5%）和环丙沙星（96.5%）耐药，8.5%对阿奇霉素耐药，分别有 10.3%和 10.3%对头孢曲松和头孢克肟的敏感性/耐药性降低，而 100%对大观霉素敏感。血根碱的最低抑菌浓度（MIC）范围、MIC、MIC 和 MIC 值分别为 2-64μg/ml、16μg/ml、32μg/ml 和 16.9μg/ml，时间杀伤曲线显示在 6 小时的检测时间内，药物呈剂量依赖性杀灭细菌，与大观霉素非常相似。血根碱具有作为一种有效和新型抗淋病奈瑟菌药物的巨大潜力。