Moremane Malebogo M, Abrahams Beynon, Tiloke Charlette
Department of Basic Medical Sciences, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, South Africa.
Curr Issues Mol Biol. 2023 Aug 18;45(8):6880-6902. doi: 10.3390/cimb45080434.
The global burden of female breast cancer and associated deaths has become a major concern. Many chemotherapeutic agents, such as doxorubicin, have been shown to have adverse side effects. The development of multi-drug resistance is a common occurrence, contributing to chemotherapeutic failure. The resistance of breast cancer cells to drug treatment leads to a decline in the treatment efficacy and an increase in cancer recurrence. Therefore, action is required to produce alternative drug therapies, such as herbal drugs. Herbal drugs have been proven to be beneficial in treating illnesses, including cancer. This review aims to highlight the antiproliferative potential of (MO), a medicinal tree native to India and indigenous to Africa, in breast cancer cells. Although MO is not yet considered a commercial chemopreventive drug, previous studies have indicated that it could become a chemotherapeutic agent. The possible antiproliferative potential of MO aqueous leaf extract has been previously proven through its antioxidant potential as well as its ability to induce apoptosis. This review will provide an increased understanding of the effect that MO aqueous leaf extract could potentially have against breast cancer.
女性乳腺癌的全球负担及相关死亡已成为一个主要关注点。许多化疗药物,如阿霉素,已被证明具有不良副作用。多药耐药性的发展很常见,导致化疗失败。乳腺癌细胞对药物治疗的耐药性导致治疗效果下降和癌症复发增加。因此,需要采取行动开发替代药物疗法,如草药。草药已被证明对治疗包括癌症在内的疾病有益。本综述旨在强调印度本土及非洲原产的药用树(MO)在乳腺癌细胞中的抗增殖潜力。尽管MO尚未被视为一种商业化学预防药物,但先前的研究表明它可能成为一种化疗药物。MO水叶提取物可能的抗增殖潜力先前已通过其抗氧化潜力以及诱导细胞凋亡的能力得到证实。本综述将增进对MO水叶提取物可能对乳腺癌产生的影响的理解。