一项关于慢性牙周炎和非酒精性脂肪性肝病的孟德尔随机研究。

A Mendelian randomization study between chronic periodontitis and non-alcoholic fatty liver disease.

机构信息

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.

出版信息

J Periodontal Res. 2024 Apr;59(2):346-354. doi: 10.1111/jre.13218. Epub 2023 Dec 15.

DOI:10.1111/jre.13218

PMID:38102730

Abstract

BACKGROUND AND OBJECTIVE

Observational studies have suggested a potential association between non-alcoholic fatty liver disease (NAFLD) and chronic periodontitis (CP). However, these studies are prone to confounding factors. The aim of this study was to assess the causal relationship between NAFLD and CP using a two-sample bidirectional Mendelian randomization (MR) analysis method.

METHODS

Datasets of CP and NAFLD were retrieved from the European database, and instrumental variables (IVs) related to exposure were selected for the MR analysis. Sensitivity tests, including heterogeneity and horizontal pleiotropy tests, were conducted to ensure the consistency of the selected IVs, following which the analysis results were visualized.

RESULTS

Genetic variants associated with CP and NAFLD were identified as IVs, and the MR assessment was performed using the summary data (CP: 3046 cases and 195 395 controls; NAFLD: 894 cases and 217 898 controls). CP increased the risk of NAFLD (inverse variance weighted [IVW], b = 0.132 > 0, p = .006 < .05), whereas the reverse was not observed (IVW, b = -0.024 < 0, p = .081 > .05). The sensitivity analysis indicated no heterogeneity or horizontal pleiotropy.

CONCLUSION

The MR analysis suggested that CP could increase the risk of NAFLD among European populations.

摘要

背景与目的

观察性研究表明，非酒精性脂肪性肝病（NAFLD）与慢性牙周炎（CP）之间可能存在关联。然而，这些研究容易受到混杂因素的影响。本研究旨在使用两样本双向孟德尔随机化（MR）分析方法评估 NAFLD 与 CP 之间的因果关系。

方法

从欧洲数据库中检索 CP 和 NAFLD 数据集，并选择与暴露相关的工具变量（IVs）进行 MR 分析。进行敏感性测试，包括异质性和水平多效性测试，以确保所选 IVs 的一致性，然后可视化分析结果。

结果

确定与 CP 和 NAFLD 相关的遗传变异作为 IVs，并使用汇总数据（CP：3046 例和 195395 例对照；NAFLD：894 例和 217898 例对照）进行 MR 评估。CP 增加了 NAFLD 的风险（逆方差加权[IVW]，b=0.132>0，p=0.006<0.05），而反之则没有观察到（IVW，b=-0.024<0，p=0.081>0.05）。敏感性分析表明不存在异质性或水平多效性。