伊拉克库尔德地区苏莱曼尼亚市希瓦癌症医院癌症患者中抗抗体的血清阳性率。
Seroprevalence of Anti- Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq.
作者信息
Mohammed Latif O, Amin Ahmed Ms, Mohammed Rezan M, Mohammed Shad A, Ahmed Lava I, Ahmed Vanya R, Majid Shaz Bd, Mohammed Bryar O
机构信息
Department of Microbiology, College of Medicine, University of Sulaimani, Sulaimani, Iraq.
Department of Biology, College of Science, University of Sulaimani, Sulaimani, Iraq.
出版信息
Iran J Parasitol. 2023 Oct-Dec;18(4):526-534. doi: 10.18502/ijpa.v18i4.14261.
BACKGROUND
is an opportunistic protozoan parasite that causes a life-threatening disease - toxoplasmosis - in immunocompromised individuals, including patients with cancer. This prospective cross-sectional study set out to determine the prevalence of toxoplasmosis in patients with cancer compared with that of healthy individuals.
METHODS
A prospective cross-sectional study was conducted in Sulaimani City of Iraq from November 2019 to May 2020. Anti- IgG and IgM antibodies were measured in the blood samples of 113 patients with cancer (80 with solid organ tumors and 33 with haematological malignancies) entered to Hiwa Cancer Hospital and 82 healthy controls, who were referred to the Directorate of Blood Transfusion for blood donation, using chemiluminescence microparticle immunoassay (CMIA).
RESULTS
The prevalence of anti- IgG was 39.8% in the patient group and 24.4% in the control group, which amounted to a significant difference ( = 0.024). Only one case of anti- IgM positivity was observed in the patient group, and no IgM seropositivity was reported in the control group. Moreover, the seroprevalence of anti- IgG was non-significantly higher ( = 0.102) in the patients with haematological malignancies (51.5%) than in those with solid organ tumors (35%). Occupation was the only risk factor which had a significant association with infection (odds ratio [OR]: 1.3, 95% confidence interval [CI]: 0.6746163 - 2.4282788, = 0.029).
CONCLUSION
The prevalence of infection is higher in patients with cancer than in healthy individuals. Therefore, screening in patients with cancer is recommended.
背景
是一种机会性原生动物寄生虫，可在包括癌症患者在内的免疫功能低下个体中引发危及生命的疾病——弓形虫病。这项前瞻性横断面研究旨在确定癌症患者与健康个体相比弓形虫病的患病率。
方法
2019年11月至2020年5月在伊拉克苏莱曼尼亚市进行了一项前瞻性横断面研究。使用化学发光微粒子免疫分析（CMIA）对进入希瓦癌症医院的113例癌症患者（80例实体器官肿瘤患者和33例血液系统恶性肿瘤患者）以及82名健康对照者（他们因献血被转介到输血管理局）的血液样本中的抗IgG和IgM抗体进行检测。
结果
患者组抗IgG的患病率为39.8%，对照组为24.4%，差异有统计学意义（=0.024）。患者组仅观察到1例抗IgM阳性病例，对照组未报告IgM血清阳性病例。此外，血液系统恶性肿瘤患者（51.5%）的抗IgG血清阳性率高于实体器官肿瘤患者（35%），但差异无统计学意义（=0.102）。职业是与感染有显著关联的唯一危险因素（优势比[OR]：1.3，95%置信区间[CI]：0.6746163 - 2.4282788，=0.029）。
结论
癌症患者中感染的患病率高于健康个体。因此，建议对癌症患者进行筛查。
Zotero 插件