用于肿瘤治疗的不同靶向配体介导的药物递送系统
Different Targeting Ligands-Mediated Drug Delivery Systems for Tumor Therapy.
作者信息
Yan Shuxin, Na Jintong, Liu Xiyu, Wu Pan
机构信息
State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning 530021, China.
School of Pharmacy, Guangxi Medical University, Nanning 530021, China.
出版信息
Pharmaceutics. 2024 Feb 7;16(2):248. doi: 10.3390/pharmaceutics16020248.
Traditional tumor treatments have the drawback of harming both tumor cells and normal cells, leading to significant systemic toxic side effects. As a result, there is a pressing need for targeted drug delivery methods that can specifically target cells or tissues. Currently, researchers have made significant progress in developing targeted drug delivery systems for tumor therapy using various targeting ligands. This review aims to summarize recent advancements in targeted drug delivery systems for tumor therapy, focusing on different targeting ligands such as folic acid, carbohydrates, peptides, aptamers, and antibodies. The review also discusses the advantages, challenges, and future prospects of these targeted drug delivery systems.
传统的肿瘤治疗方法存在损害肿瘤细胞和正常细胞的缺点，会导致严重的全身毒性副作用。因此，迫切需要能够特异性靶向细胞或组织的靶向给药方法。目前，研究人员在使用各种靶向配体开发用于肿瘤治疗的靶向给药系统方面取得了重大进展。本综述旨在总结肿瘤治疗靶向给药系统的最新进展，重点关注不同的靶向配体，如叶酸、碳水化合物、肽、适体和抗体。本综述还讨论了这些靶向给药系统的优点、挑战和未来前景。
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