人乳头瘤病毒阳性头颈部鳞状细胞癌的免疫微环境。
Immune microenvironment of human papillomavirus-positive head and neck squamous cell carcinoma.
机构信息
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, China.
Laboratory of Allergy and Precision Medicine, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
出版信息
Sci Prog. 2024 Jan-Mar;107(1):368504241237888. doi: 10.1177/00368504241237888.
OBJECTIVES
Research progress of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) based on immune microenvironment.
METHODS
This article preliminarily discusses the composition of immune microenvironment components and immune therapy and elaborates and analyzes the involvement and impact of T cells, B cells, natural killer (NK) cells, tumor-associated fibroblasts, and bone marrow-derived suppressor cells in HPV-positive HNSCC on tumor progression and prognosis. Furthermore, the application of immune-related therapies in HPV-positive HNSCC is explored.
RESULTS
It is found that immune microenvironment research plays an important role in the pathogenesis and treatment of HPV-positive HNSCC.
CONCLUSIONS
Immune microenvironment research as an important means to explore tumors has played an important role in the study of HPV-positive HNSCC. We describe the biological significance of important components of HNSCC immune microenvironment by analyzing the effects of HNSCC immune microenvironment components and immunotherapy on HPV-positive HNSCC. May to provide new strategies for experimental research and clinical prevention and treatment of this disease.
目的
基于免疫微环境探讨人乳头瘤病毒（HPV）阳性头颈部鳞状细胞癌（HNSCC）的研究进展。
方法
本文初步探讨了免疫微环境成分和免疫治疗的组成，阐述和分析了 T 细胞、B 细胞、自然杀伤（NK）细胞、肿瘤相关成纤维细胞和骨髓来源的抑制细胞在 HPV 阳性 HNSCC 中对肿瘤进展和预后的影响。此外，还探讨了免疫相关治疗在 HPV 阳性 HNSCC 中的应用。
结果
发现免疫微环境研究在 HPV 阳性 HNSCC 的发病机制和治疗中起着重要作用。
结论
免疫微环境研究作为探索肿瘤的重要手段，在 HPV 阳性 HNSCC 的研究中发挥了重要作用。通过分析 HNSCC 免疫微环境成分和免疫治疗对 HPV 阳性 HNSCC 的影响，我们描述了 HNSCC 免疫微环境重要成分的生物学意义。可能为该疾病的实验研究和临床防治提供新的策略。
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