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近期欧洲婴儿百日咳病例增加,产前免疫接种至关重要:我们必须做得更好……现在。

Recent increase in infant pertussis cases in Europe and the critical importance of antenatal immunizations: We must do better…now.

机构信息

Fetal Medicine Unit, St George's Hospital, St George's University of London, London, UK; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK; The Royal College of Obstetricians and Gynaecologists, London, UK.

Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden; FUTURE, Center for Functional Tissue Reconstruction, University of Oslo, Oslo, Norway.

出版信息

Int J Infect Dis. 2024 Sep;146:107148. doi: 10.1016/j.ijid.2024.107148. Epub 2024 Jul 2.

Abstract

Recent months have seen an increase in pertussis cases in several countries across the Northern and Southern hemispheres. The lack of immune stimulation during the COVID-19 pandemic due to the reduced circulation of Bordetella pertussis, the pathogen responsible for pertussis, is likely to have led to increased population susceptibility which has been magnified the typical three to five yearly cyclical peaks in activity. Maternal immunization for pertussis proves highly effective in protecting infants under three months of age. It's also critical for immunizers and parents to maintain high and timely immunization uptake to ensure infants receive maximum early protection when they are most at risk of severe disease.

摘要

最近几个月,南北半球的几个国家百日咳病例都有所增加。由于引起百日咳的病原体百日咳博德特氏菌的传播减少,在 COVID-19 大流行期间免疫刺激减少,可能导致人群易感性增加,使百日咳的活动典型的每三到五年周期性高峰加剧。针对百日咳的母体免疫接种被证明对保护三个月以下婴儿非常有效。免疫接种人员和家长也必须保持高和及时的免疫接种率,以确保婴儿在最容易患重病时获得最大的早期保护。

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