Department of Physiology, Schools of Pharmacy and Medicine, University of Granada, 18071 Granada, Spain.
Biomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, Spain.
Nutrients. 2024 Aug 21;16(16):2790. doi: 10.3390/nu16162790.
Cancer remains a public health concern worldwide, with its incidence increasing worldwide and expected to continue growing during the next decades. The microbiome has emerged as a central factor in human health and disease, demonstrating an intricate relationship between the microbiome and cancer. Although some microbiomes present within local tissues have been shown to restrict cancer development, mainly by interacting with cancer cells or the host immune system, some microorganisms are harmful to human health and risk factors for cancer development. This review summarizes the recent evidence concerning the microbiome and some of the most common cancer types (i.e., lung, head and neck, breast, gastric, colorectal, prostate, and cervix cancers), providing a general overview of future clinical approaches and perspectives.
癌症仍然是一个全球性的公共卫生关注点,其发病率在全球范围内不断上升,预计在未来几十年内还将继续增长。微生物组已成为人类健康和疾病的核心因素,展示了微生物组与癌症之间复杂的关系。虽然一些存在于局部组织内的微生物组已被证明可以限制癌症的发展,主要是通过与癌细胞或宿主免疫系统相互作用,但一些微生物对人类健康有害,是癌症发展的危险因素。本综述总结了有关微生物组和一些最常见癌症类型(即肺癌、头颈部癌、乳腺癌、胃癌、结直肠癌、前列腺癌和宫颈癌)的最新证据,提供了未来临床方法和观点的概述。