LncRNA Promotes Bladder Uroepithelial Cancer Progression by Stabilizing DDX5.

Exploration of molecular markers is an ongoing focus in the field of bladder cancer research. Based on data from public databases, was identified as upregulated in bladder urothelial carcinoma (BLCA); however, its exact function and regulatory mechanism in this context remain unclear. To investigate the clinical implications of , we examined its levels in 90 BLCA and adjoining normal tissue samples. Functional assays were conducted to assess the effects of on BLCA cell proliferation, migration, and invasion. Animal assays were employed to determine the effects of on BLCA tumorigenicity . Immunoblotting, RNA pull-down, RNA immunoprecipitation, TOP/FOP luciferase reporter gene, and coimmunoprecipitation assays were used to explore the molecular mechanism underlying the effects of on BLCA progression. expression was significantly up-regulated in BLCA tissues and correlated with pathological stage, grade, and poor patient outcome. Altered levels promoted BLCA proliferation, migration, and invasion. Mechanistic studies suggested that interacts with DDX5 protein, enhances its stability, and ultimately leads to BLCA progression through Wnt/β-catenin signaling pathway activation. overexpression increases the aggressiveness of BLCA by activating the Wnt/β-catenin pathway through binding to DDX5. has potential as a new molecular predictor of poor prognosis in patients with BLCA.