急性疼痛与围手术期阿片类镇痛中的遗传学与性别因素

Genetics and Gender in Acute Pain and Perioperative Opioid Analgesia.

作者信息

Nagella Amrutha Bindu, Yalamuru Bhavana

机构信息

Rehabilitation Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.

Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA.

出版信息

Anesthesiol Clin. 2025 Mar;43(1):127-140. doi: 10.1016/j.anclin.2024.08.001. Epub 2024 Sep 17.

DOI:10.1016/j.anclin.2024.08.001

PMID:39890315

Abstract

Biological sex as a variable in pain perception has been rigorously studied. However, there is little correlation between clinical and experimental studies with regard to this. There has been a surge of interest and research in the correlation of genes and single-nucleotide polymorphisms in relation to pain perception, and opioid pharmacokinetics. However, there have not yet been studies or reports of generalized application of this testing to improve acute postoperative pain outcomes.

摘要

生物性别作为疼痛感知中的一个变量已得到深入研究。然而，临床研究与实验研究在这方面几乎没有相关性。关于基因和单核苷酸多态性与疼痛感知以及阿片类药物药代动力学之间的相关性，已有大量的研究兴趣和相关研究。然而，尚未有关于将该检测广泛应用于改善术后急性疼痛结局的研究或报告。