基于再生医学的皮肤再生与年轻化方法的进展。
Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation.
作者信息
Dutra Alves Nathalia Silva, Reigado Gustavo Roncoli, Santos Mayara, Caldeira Izabela Daniel Sardinha, Hernandes Henrique Dos Santos, Freitas-Marchi Bruna Leticia, Zhivov Elina, Chambergo Felipe Santiago, Nunes Viviane Abreu
机构信息
Laboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.
Laboratory of Proteins and Biotechnology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.
出版信息
Front Bioeng Biotechnol. 2025 Feb 12;13:1527854. doi: 10.3389/fbioe.2025.1527854. eCollection 2025.
Significant progress has been made in regenerative medicine for skin repair and rejuvenation. This review examines core technologies including stem cell therapy, bioengineered skin substitutes, platelet-rich plasma (PRP), exosome-based therapies, and gene editing techniques like CRISPR. These methods hold promise for treating a range of conditions, from chronic wounds and burns to age-related skin changes and genetic disorders. Challenges remain in optimizing these therapies for broader accessibility and ensuring long-term safety and efficacy.
再生医学在皮肤修复和年轻化方面取得了重大进展。本综述探讨了核心技术，包括干细胞疗法、生物工程皮肤替代物、富血小板血浆（PRP）、基于外泌体的疗法以及CRISPR等基因编辑技术。这些方法有望治疗一系列病症，从慢性伤口和烧伤到与年龄相关的皮肤变化和遗传疾病。在优化这些疗法以使其更易于获得以及确保长期安全性和有效性方面仍存在挑战。
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