心理教育项目可提高双相情感障碍患者的端粒酶活性：一项基于性别的随机对照试验。

Psychoeducational Program Increases Telomerase Activity in Bipolar Disorder: A Gender-Based Randomized Controlled Trial.

作者信息

Massa G, Bruno F, Tarsitani L, Caredda M, Biondi M, Bevilacqua A, Canterini S

机构信息

Division of Neuroscience, Department of Psychology, University La Sapienza, Rome, Italy.

PhD Program in Behavioral Neuroscience, Sapienza University of Rome, Rome, Italy.

出版信息

CNS Neurosci Ther. 2025 Apr;31(4):e70292. doi: 10.1111/cns.70292.

DOI:10.1111/cns.70292

PMID:40205817

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11982523/

Abstract

AIMS

This randomized controlled trial evaluated the efficacy of a psychoeducational program in enhancing telomerase activity (TA) among patients with bipolar disorder (BD), with a specific focus on gender differences.

METHODS

A total of 62 participants were assigned to either the psychoeducation (PE) group or the control (CTR) group, with TA measured both before and after the intervention.

RESULTS

Results demonstrated a significant increase in TA in the PE group compared to the controls at the conclusion of the study. Notably, gender-specific analyses revealed that female participants showed significant increases in both TA and delta TA (Δ), with Δ PE = 0.586 ± 0.273 and Δ CTR = -0.251 ± 0.177. In contrast, male participants exhibited significant changes only in Δ, with Δ PE = 0.257 ± 0.138 and Δ CTR = -0.144 ± 0.1194.

CONCLUSION

These findings suggest that psychoeducational interventions have differential gender-specific effects, underscoring the importance of personalized approaches in the treatment of BD.

摘要

目的

本随机对照试验评估了心理教育项目在提高双相情感障碍（BD）患者端粒酶活性（TA）方面的疗效，特别关注性别差异。

方法

共有62名参与者被分配到心理教育（PE）组或对照组（CTR），在干预前后均测量TA。

结果

研究结束时，结果表明PE组的TA相比对照组有显著增加。值得注意的是，性别特异性分析显示，女性参与者的TA和TA变化量（Δ）均有显著增加，Δ PE = 0.586 ± 0.273，Δ CTR = -0.251 ± 0.177。相比之下，男性参与者仅在Δ上有显著变化，Δ PE = 0.257 ± 0.138，Δ CTR = -0.144 ± 0.1194。