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The Complexity of SIRT2 in Chronic Liver Disease: Liver SIRT2 Promotes Hepatocellular Carcinoma Development.

作者信息

Li Xinjian, Lu Shaolei, Huang Chiung-Kuei

机构信息

Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana.

Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island.

出版信息

Cell Mol Gastroenterol Hepatol. 2025;19(7):101512. doi: 10.1016/j.jcmgh.2025.101512. Epub 2025 Apr 22.

Abstract
摘要

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本文引用的文献

1
Suppression of Hepatocellular Carcinoma by Deletion of SIRT2 in Hepatocytes via Elevated C/EBPβ/GADD45γ.
Cell Mol Gastroenterol Hepatol. 2025;19(7):101494. doi: 10.1016/j.jcmgh.2025.101494. Epub 2025 Mar 11.
2
Management of Hepatocellular Carcinoma: A Review.
JAMA Surg. 2023 Apr 1;158(4):410-420. doi: 10.1001/jamasurg.2022.7989.
3
Hepatocellular carcinoma.
Lancet. 2022 Oct 15;400(10360):1345-1362. doi: 10.1016/S0140-6736(22)01200-4. Epub 2022 Sep 6.
5
SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury.
Cell Discov. 2021 Oct 12;7(1):93. doi: 10.1038/s41421-021-00326-6.
6
Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α.
Hepatology. 2021 Aug;74(2):723-740. doi: 10.1002/hep.31773. Epub 2021 May 24.
7
Hepatocellular carcinoma.
Nat Rev Dis Primers. 2021 Jan 21;7(1):6. doi: 10.1038/s41572-020-00240-3.
8
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells.
Cell Metab. 2020 Sep 1;32(3):420-436.e12. doi: 10.1016/j.cmet.2020.07.008. Epub 2020 Aug 7.
10
Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma.
N Engl J Med. 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745.

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