环状RNA后起之秀：circPRMT5在癌症中的新发现
Circular RNA rising star: new findings of circPRMT5 in cancer.
作者信息
Chen DuanZhong, Yin CaiYan, Li Chao, He Jun, Wu Peng
机构信息
Department of Clinical Laboratory, Hengyang Medical School, The Affiliated Nanhua Hospital, University of South China, Hengyang, 421001, Hunan, China.
Hengyang Maternal and Child Health Hospital, Hengyang, 421001, Hunan, China.
出版信息
Mol Biol Rep. 2025 Jun 18;52(1):613. doi: 10.1007/s11033-025-10638-5.
Circular RNA (circRNA), a type of noncoding RNA, features a covalently closed circular structure lacking 5'-3' polarity and a polyadenylated tail. Its resistance to RNase R degradation endows it with greater stability and resilience than linear RNA, leading to a prolonged half-life. Recent research has highlighted the crucial role of circRNAs, especially circPRMT5, in diverse cancers. CircPRMT5 is generated by reverse splicing of exon 18 within a 682-nucleotide gene. In various cancer cells, elevated circPRMT5 expression is correlated with increased tumor cell proliferation, migration, and invasion abilities. It impacts tumor progression by regulating cell proliferation, migration, invasion, and chemotherapy resistance. This review comprehensively examines the expression patterns, mechanisms, and clinical potential of circPRMT5 in cancers such as breast, bladder, nonsmall cell lung, esophageal, thyroid, liver, colorectal, and gastric cancer. Overall, circPRMT5 shows promise as a biomarker and therapeutic target, providing valuable insights for future cancer research and treatment strategies.
环状RNA（circRNA）是一种非编码RNA，其特征在于具有共价闭合的环状结构，缺乏5'-3'极性和聚腺苷酸化尾巴。它对RNase R降解的抗性使其比线性RNA具有更高的稳定性和弹性，从而导致半衰期延长。最近的研究突出了环状RNA，尤其是circPRMT5，在多种癌症中的关键作用。CircPRMT5由一个682个核苷酸基因内的第18外显子反向剪接产生。在各种癌细胞中，circPRMT5表达升高与肿瘤细胞增殖、迁移和侵袭能力增强相关。它通过调节细胞增殖、迁移、侵袭和化疗抗性来影响肿瘤进展。本综述全面研究了circPRMT5在乳腺癌、膀胱癌、非小细胞肺癌、食管癌、甲状腺癌、肝癌、结直肠癌和胃癌等癌症中的表达模式、机制及临床潜力。总体而言，circPRMT5有望成为一种生物标志物和治疗靶点，为未来癌症研究和治疗策略提供有价值的见解。
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