沙特阿拉伯一家三级护理医院十年的抗菌药物耐药性趋势：见解（2013 - 2022年）
A decade of antimicrobial resistance trends in : insights from a tertiary care hospital in Saudi Arabia (2013-2022).
作者信息
Shabi Yahya, Algarni Abdullah, Al Bshabshe Ali, Alazraqi Tarik, Patriquin Glenn, Bawazeer Abdulah Os, Mohammed Safia Abdullah, Habbash Sara, Somily Ali, Alqahtani Abdulah J, Alhamhhum Saeed M S
机构信息
Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Department of Family Medicine, Aseer Central Hospital, Abha, Saudi Arabia.
出版信息
Front Microbiol. 2025 Jul 7;16:1617522. doi: 10.3389/fmicb.2025.1617522. eCollection 2025.
BACKGROUND
(PA) is a significant cause of nosocomial infections, and increasing antimicrobial resistance complicates management.
OBJECTIVES
To characterize antimicrobial susceptibility trends, we conducted a retrospective study of PA clinical isolates over 10 years (2013-2022) at a tertiary care hospital in Saudi Arabia.
RESULTS
A total of 2,490 PA isolates were analyzed (1,452 from general wards and 1,038 from ICUs). Carbapenem resistance was observed in 40% of isolates; 37.5% were multidrug-resistant (MDR), 5.3% were extensively drug-resistant (XDR), and 3.5% met the criteria for difficult-to-treat resistance (DTR).
CONCLUSION
This study provides an overview of PA resistance pattern trends in Saudi Arabia and emphasizes the importance of establishing an antimicrobial stewardship program.
背景
肺炎克雷伯菌是医院感染的重要原因，抗菌药物耐药性增加使管理变得复杂。
目的
为了描述抗菌药物敏感性趋势，我们对沙特阿拉伯一家三级医院10年（2013 - 2022年）期间的肺炎克雷伯菌临床分离株进行了一项回顾性研究。
结果
共分析了2490株肺炎克雷伯菌分离株（1452株来自普通病房，1038株来自重症监护病房）。40%的分离株观察到对碳青霉烯类耐药；37.5%为多重耐药（MDR），5.3%为广泛耐药（XDR），3.5%符合难治性耐药（DTR）标准。
结论
本研究概述了沙特阿拉伯肺炎克雷伯菌耐药模式趋势，并强调了建立抗菌药物管理计划的重要性。
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