作为癌症生物标志物的染色体外环状DNA：从诊断到治疗
Extrachromosomal Circular DNA as a Cancer Biomarker: From Diagnosis to Treatment.
作者信息
Li Hexin, Cai Jiahui, Zhao Gang, Zou Lihui
机构信息
Clinical Biobank, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China.
Department of General Surgery Beijing Hospital Beijing China.
出版信息
Cancer Innov. 2025 Sep 8;4(5):e70026. doi: 10.1002/cai2.70026. eCollection 2025 Oct.
Extrachromosomal circular DNA (eccDNA) is an emerging class of genetic material that exists outside of the chromosomal genome. These circular DNA molecules are gaining increasing attention as important biomarkers in various cancers because of their roles in gene amplification, genetic heterogeneity, and drug resistance. In this review, we explore in depth the impacts of eccDNAs on cancer biology, their potential to predict treatment sensitivity and resistance, and their involvement in the development of new anticancer therapies. eccDNAs can be used as biomarkers for various tumor types to help diagnose and predict prognosis.
染色体外环状DNA（eccDNA）是一类新兴的遗传物质，存在于染色体基因组之外。由于这些环状DNA分子在基因扩增、遗传异质性和耐药性方面发挥作用，它们作为各种癌症中的重要生物标志物正受到越来越多的关注。在这篇综述中，我们深入探讨了eccDNA对癌症生物学的影响、它们预测治疗敏感性和耐药性的潜力，以及它们在新型抗癌疗法开发中的作用。eccDNA可作为各种肿瘤类型的生物标志物，以帮助诊断和预测预后。
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