新生儿体内的炎性细胞因子
Inflammatory cytokines in newborn infants.
作者信息
Sarandakou A, Giannaki G, Malamitsi-Puchner A, Rizos D, Hourdaki E, Protonotariou E, Phocas I
机构信息
2nd Department of Obstetrics and Gynaecology, Areteion University Hospital, Athens, Greece.
出版信息
Mediators Inflamm. 1998;7(5):309-12. doi: 10.1080/09629359890811.
Serum levels of IL-1beta, IL-6 and TNF-alpha were measured in 48 healthy, termed neonates on the 1st (N1), 5th (N5) and 40th (N40) day after birth, compared with those in maternal serum (MS), umbilical cord (UC) and adult controls. Cytokine values in N1 and N5 were significantly elevated, than those in UC and in controls (P<0.0001). IL-1beta and IL-6 declined significantly from N1 to N40 (P<0.0001), while TNF-alpha increased significantly from N1 to N5 and declined thereafter. MS infinity IL-1beta and IL-6, but not MS infinity TNF-alpha, were significantly higher than those of controls (P<0.0001). IL-1beta values depended on the mode of delivery. In conclusion, the increased concentrations of IL-1beta, IL-6 and TNF-alpha during the perinatal period might suggest their involvement in an inflammation-like process during normal parturition, and reflect also a newborn immune response to the stress of delivery and environmental changes.
在48名健康足月儿出生后的第1天（N1）、第5天（N5）和第40天（N40）测量其血清白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平，并与母血（MS）、脐带血（UC）及成人对照组进行比较。N1和N5时细胞因子水平显著高于UC和对照组（P<0.0001）。从N1到N40，IL-1β和IL-6显著下降（P<0.0001），而TNF-α从N1到N5显著升高，此后下降。母血中的IL-1β和IL-6，但不包括母血中的TNF-α，显著高于对照组（P<0.0001）。IL-1β水平取决于分娩方式。总之，围产期IL-1β、IL-6和TNF-α浓度升高可能表明它们参与了正常分娩过程中的类似炎症反应，也反映了新生儿对分娩应激和环境变化的免疫反应。
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