糖尿病幼虫与肥胖果蝇——果蝇新陈代谢的新兴研究
Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila.
作者信息
Baker Keith D, Thummel Carl S
机构信息
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112-5331, USA.
出版信息
Cell Metab. 2007 Oct;6(4):257-66. doi: 10.1016/j.cmet.2007.09.002.
Abstract
The past few years have seen a shift in the use of Drosophila, from studies of growth and development toward genetic characterization of carbohydrate, sterol, and lipid metabolism. This research, reviewed below, establishes a new foundation for using this simple genetic model system to define the basic regulatory mechanisms that underlie metabolic homeostasis and holds the promise of providing new insights into the causes and treatments of critical human disorders such as diabetes and obesity.
摘要
在过去几年中，果蝇的用途发生了转变，从生长发育研究转向碳水化合物、固醇和脂质代谢的遗传特征研究。下面回顾的这项研究，为利用这个简单的遗传模型系统来定义代谢稳态背后的基本调控机制奠定了新基础，并有望为糖尿病和肥胖症等严重人类疾病的病因和治疗提供新见解。
相似文献
1
Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila.
Cell Metab. 2007 Oct;6(4):257-66. doi: 10.1016/j.cmet.2007.09.002.
2
Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism.
BMC Biol. 2012 Jul 24;10:63. doi: 10.1186/1741-7007-10-63.
3
Amino acids and the humoral regulation of growth: fat bodies use slimfast.
Cell. 2003 Sep 19;114(6):656-8. doi: 10.1016/s0092-8674(03)00721-9.
4
Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway.
J Cell Biol. 2007 Dec 17;179(6):1105-13. doi: 10.1083/jcb.200709044.
5
Drosophila p53-related protein kinase is required for PI3K/TOR pathway-dependent growth.
Development. 2013 Mar;140(6):1282-91. doi: 10.1242/dev.086918.
6
Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster.
Genetics. 2010 May;185(1):189-98. doi: 10.1534/genetics.110.114975. Epub 2010 Feb 22.
7
The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner.
Mol Biol Cell. 2014 Mar;25(6):916-24. doi: 10.1091/mbc.E13-04-0213. Epub 2014 Jan 15.
8
Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila.
Genes Dev. 2011 Jan 15;25(2):189-200. doi: 10.1101/gad.1992411.
9
Chewing the fat; regulating autophagy in Drosophila.
Dev Cell. 2004 Aug;7(2):148-50. doi: 10.1016/j.devcel.2004.07.014.
10
Drosophila Melted modulates FOXO and TOR activity.
Dev Cell. 2005 Aug;9(2):271-81. doi: 10.1016/j.devcel.2005.07.004.
引用本文的文献
1
Identification of SEC16B as a novel regulator of glucose homeostasis.
Diabetologia. 2025 Jul 24. doi: 10.1007/s00125-025-06501-8.
2
Developmental mitochondrial complex I activity determines lifespan.
EMBO Rep. 2025 Apr;26(8):1957-1983. doi: 10.1038/s44319-025-00416-6. Epub 2025 Mar 17.
3
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites.
Nat Commun. 2025 Mar 3;16(1):2135. doi: 10.1038/s41467-025-57405-5.
4
Nutritional state-dependent modulation of insulin-producing cells in .
Elife. 2025 Jan 29;13:RP98514. doi: 10.7554/eLife.98514.
5
Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production.
Life Metab. 2024 Jan 18;3(2):loae004. doi: 10.1093/lifemeta/loae004. eCollection 2024 Apr.
6
Exploring the versatility of as a model organism in biomedical research: a comprehensive review.
Fly (Austin). 2025 Dec;19(1):2420453. doi: 10.1080/19336934.2024.2420453. Epub 2024 Dec 25.
7
Metabolic rewiring in fat-depleted Drosophila reveals triglyceride:glycogen crosstalk and identifies cDIP as a new regulator of energy metabolism.
Res Sq. 2024 Oct 18:rs.3.rs-4505077. doi: 10.21203/rs.3.rs-4505077/v1.
8
Correlated changes in stress resistance and biochemical parameters in response to long-term protein restriction in .
R Soc Open Sci. 2024 Jun 5;11(6):231741. doi: 10.1098/rsos.231741. eCollection 2024 Jun.
9
The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy.
Cell Rep. 2024 Aug 27;43(8):114549. doi: 10.1016/j.celrep.2024.114549. Epub 2024 Aug 1.
10
Koidz. and Lam. extract relieves insulin resistance via PI3K/Akt signalling in diabetic .
J Tradit Complement Med. 2024 Jan 31;14(4):424-434. doi: 10.1016/j.jtcme.2024.01.010. eCollection 2024 Jul.
本文引用的文献
1
Adipose is a conserved dosage-sensitive antiobesity gene.
Cell Metab. 2007 Sep;6(3):195-207. doi: 10.1016/j.cmet.2007.08.001.
2
Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways.
Mol Genet Metab. 2007 Jul;91(3):209-17. doi: 10.1016/j.ymgme.2007.03.011. Epub 2007 May 22.
3
Dual lipolytic control of body fat storage and mobilization in Drosophila.
PLoS Biol. 2007 Jun;5(6):e137. doi: 10.1371/journal.pbio.0050137.
4
Niemann-Pick C proteins in sterol transport and absorption: flies in the ointment.
Dev Cell. 2007 Apr;12(4):481-3. doi: 10.1016/j.devcel.2007.03.017.
5
Drosophila NPC1b promotes an early step in sterol absorption from the midgut epithelium.
Cell Metab. 2007 Mar;5(3):195-205. doi: 10.1016/j.cmet.2007.01.011.
6
The role of larval fat cells in adult Drosophila melanogaster.
J Exp Biol. 2007 Mar;210(Pt 6):956-63. doi: 10.1242/jeb.001586.
7
ATF-2 regulates fat metabolism in Drosophila.
Mol Biol Cell. 2007 Apr;18(4):1519-29. doi: 10.1091/mbc.e06-10-0909. Epub 2007 Feb 21.
8
How flies get their size: genetics meets physiology.
Nat Rev Genet. 2006 Dec;7(12):907-16. doi: 10.1038/nrg1989.
9
Specialized hepatocyte-like cells regulate Drosophila lipid metabolism.
Nature. 2007 Jan 18;445(7125):275-80. doi: 10.1038/nature05382. Epub 2006 Nov 29.
10
The Halloween genes code for cytochrome P450 enzymes mediating synthesis of the insect moulting hormone.
Biochem Soc Trans. 2006 Dec;34(Pt 6):1256-60. doi: 10.1042/BST0341256.
Zotero 插件