发射俄歇电子的放射性核素的分子和细胞放射生物学效应。
Molecular and cellular radiobiological effects of Auger emitting radionuclides.
作者信息
Kassis Amin I
机构信息
Department of Radiology, Harvard Medical School, 200 Longwood Avenue, Armenise Building Room D2-137, Boston, MA 02115, USA.
出版信息
Radiat Prot Dosimetry. 2011 Feb;143(2-4):241-7. doi: 10.1093/rpd/ncq385. Epub 2010 Nov 24.
Although the general radiobiologic principles underlying external beam therapy and radionuclide therapy are similar, significant differences in the biophysical and radiobiologic effects from the two types of radiation continue to accumulate. Here, I will address the unique features that distinguish the molecular and cellular radiobiological effects of Auger electron-emitting radionuclides consequent to (1) the physical characteristics of the decaying atom and its subcellular localisation, (2) DNA topology and (3) the bystander effect. Based on these experimental findings, I postulate that the ability of track structural simulations as primary tools in modelling DNA damage and cellular survival at the molecular level would be greatly enhanced when these contributions are factored in.
尽管外照射放疗和放射性核素治疗所依据的一般放射生物学原理相似，但这两种辐射在生物物理和放射生物学效应方面的显著差异仍在不断积累。在此，我将阐述俄歇电子发射放射性核素在分子和细胞放射生物学效应方面的独特特征，这些特征源自：(1) 衰变原子的物理特性及其亚细胞定位；(2) DNA拓扑结构；(3) 旁观者效应。基于这些实验结果，我推测，当将这些因素考虑在内时，作为在分子水平上模拟DNA损伤和细胞存活的主要工具，径迹结构模拟的能力将得到极大增强。
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