实体瘤中肿瘤起始细胞的常见标志物带来的启示。
Lessons from common markers of tumor-initiating cells in solid cancers.
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377 Munich, Germany.
出版信息
Cell Mol Life Sci. 2011 Dec;68(24):4009-22. doi: 10.1007/s00018-011-0772-9. Epub 2011 Jul 24.
Tumor-initiating cells (TICs) have emerged as the driving force of carcinomas, which appear as hierarchically structured. TICs as opposed to the tumor bulk display tumor forming potential, which is linked to a certain degree of self-renewal and differentiation, both major features of stem cells. Markers such as CD44, CD133, CD24, EpCAM, CD166, Lgr5, CD47, and ALDH have been described, which allow for the prospective enrichment of TICs. It is conspicuous that the same markers allow for an enrichment of TICs in various entities and, on the other hand, that different combinations of these markers were independently reported for the same tumor entity. Potential functions of these markers in the regulation of TIC phenotypes remained somewhat neglected although they might give insights in common molecular themes of TICs. The present review discusses major TIC markers with respect to their function and potential contributions to the tumorigenic phenotype of TICs.
肿瘤起始细胞（TICs）已成为癌的驱动因素，这些细胞表现出层次结构。与肿瘤大部分不同，TICs 具有肿瘤形成潜力，这与一定程度的自我更新和分化有关，而自我更新和分化是干细胞的主要特征。已经描述了诸如 CD44、CD133、CD24、EpCAM、CD166、Lgr5、CD47 和 ALDH 等标记物，这些标记物允许 TICs 的前瞻性富集。值得注意的是，相同的标记物允许在各种实体中富集 TICs，另一方面，不同组合的这些标记物被独立地报告用于相同的肿瘤实体。尽管这些标记物可能为 TIC 的共同分子主题提供了一些见解，但它们在调节 TIC 表型中的潜在功能仍有些被忽视。本文综述了主要的 TIC 标记物，讨论了它们的功能及其对 TIC 肿瘤发生表型的潜在贡献。
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