甲状腺癌的诊断与治疗新进展。
New developments in the diagnosis and treatment of thyroid cancer.
机构信息
Assistant Professor of Surgery, Section of Endocrine Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
出版信息
CA Cancer J Clin. 2013 Nov-Dec;63(6):374-94. doi: 10.3322/caac.21195. Epub 2013 Jun 24.
Thyroid cancer exists in several forms. Differentiated thyroid cancers include those with papillary and follicular histologies. These tumors exist along a spectrum of differentiation, and their incidence continues to climb. A number of advances in the diagnosis and treatment of differentiated thyroid cancers now exist. These include molecular diagnostics and more advanced strategies for risk stratification. Medullary cancer arises from the parafollicular cells and not the follicular cells. Therefore, diagnosis and treatment differs from those of differentiated thyroid tumors. Genetic testing and newer adjuvant therapies have changed the diagnosis and treatment of medullary thyroid cancer. This review will focus on the epidemiology, diagnosis, workup, and treatment of both differentiated and medullary thyroid cancers, focusing specifically on newer developments in the field.
甲状腺癌有多种类型。分化型甲状腺癌包括乳头状癌和滤泡状癌。这些肿瘤沿着分化程度的谱系存在，其发病率持续上升。目前在分化型甲状腺癌的诊断和治疗方面取得了一些进展。这些进展包括分子诊断和更先进的风险分层策略。髓样癌来源于滤泡旁细胞，而不是滤泡细胞。因此，其诊断和治疗与分化型甲状腺肿瘤不同。基因检测和新型辅助治疗改变了髓样甲状腺癌的诊断和治疗。本综述将重点讨论分化型和髓样甲状腺癌的流行病学、诊断、检查和治疗，特别关注该领域的新进展。
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