儿童期和成年期肥胖与邻苯二甲酸盐关联中的年龄和性别差异：2007 - 2010年美国国家健康与营养检查调查分析
Age and sex differences in childhood and adulthood obesity association with phthalates: analyses of NHANES 2007-2010.
作者信息
Buser Melanie C, Murray H Edward, Scinicariello Franco
机构信息
Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA 30341, USA.
Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA 30341, USA.
出版信息
Int J Hyg Environ Health. 2014 Jul;217(6):687-94. doi: 10.1016/j.ijheh.2014.02.005. Epub 2014 Mar 5.
BACKGROUND
Exposure to environmental chemicals may play a role in the development of obesity. Evidence suggests phthalate exposure may be associated with obesity in children and adults.
OBJECTIVE
To examine the association of ten urinary phthalate metabolites mono-n-butyl phthalate (MnBP), mono-ethyl phthalate (MEP), mono-isobutyl phthalate (MiBP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-2-ethylhexyl phthalate (MEHP), mono-benzyl phthalate (MBzP), mono-(carboxylnonyl) phthalate (MCNP), and mono-(carboxyoctyl) phthalate (MCOP) grouped by molecular weight of their parent compounds with body weight outcomes in children, adolescent and adult participants in the National Health and Nutrition Examination Survey (NHANES) 2007-2010.
METHODS
We performed multinomial logistic regression to analyze the association between obesity and urinary phthalate metabolite concentrations in children and adolescents and adults.
RESULTS
Low molecular weight (LMW) phthalate metabolites (MnBP, MEP and MiBP) are significantly (p<0.05) associated with higher odds for obesity in male children and adolescents. High molecular weight (HMW) phthalate metabolites (MECPP, MEHHP, MEOHP, MEHP, MBzP, MCNP, and MCOP) and di-2-ethylhexyl phthalate (DEHP) metabolites (MEHHP, MEOHP, MEHP and MECPP) are significantly (p<0.05) associated with higher OR for obesity in all adults. Additionally, DEHP metabolites are significantly associated with obesity in all female adults; whereas DEHP and HMW metabolites are significantly associated with OR for obesity in males 60 years and older.
CONCLUSIONS
We found age and sex differences in the association between urinary phthalate metabolite concentrations and body weight outcomes. Reverse causation cannot be excluded since overweight and obese people will have more fat mass, they may store more phthalates, thus leading to higher excretion concentrations.
背景
接触环境化学物质可能在肥胖症的发展中起作用。有证据表明，邻苯二甲酸盐暴露可能与儿童和成人的肥胖症有关。
目的
在2007 - 2010年美国国家健康与营养检查调查（NHANES）的儿童、青少年和成人参与者中，研究按母体化合物分子量分组的十种尿邻苯二甲酸酯代谢物单正丁基邻苯二甲酸酯（MnBP）、单乙基邻苯二甲酸酯（MEP）、单异丁基邻苯二甲酸酯（MiBP）、单 - 2 - 乙基 - 5 - 羧基戊基邻苯二甲酸酯（MECPP）、单 - 2 - 乙基 - 5 - 羟基己基邻苯二甲酸酯（MEHHP）、单 -（2 - 乙基 - 5 - 氧代己基）邻苯二甲酸酯（MEOHP）、单 - 2 - 乙基己基邻苯二甲酸酯（MEHP）、单苄基邻苯二甲酸酯（MBzP）、单 -（羧基壬基）邻苯二甲酸酯（MCNP）和单 -（羧基辛基）邻苯二甲酸酯（MCOP）与体重结果之间的关联。
方法
我们进行多项逻辑回归分析，以研究儿童、青少年和成人中肥胖症与尿邻苯二甲酸酯代谢物浓度之间的关联。
结果
低分子量（LMW）邻苯二甲酸酯代谢物（MnBP、MEP和MiBP）与男性儿童和青少年肥胖几率较高显著相关（p<0.05）。高分子量（HMW）邻苯二甲酸酯代谢物（MECPP、MEHHP、MEOHP、MEHP、MBzP、MCNP和MCOP）以及邻苯二甲酸二（2 - 乙基己基）酯（DEHP）代谢物（MEHHP、MEOHP、MEHP和MECPP）与所有成年人肥胖的较高比值比显著相关（p<0.05）。此外，DEHP代谢物与所有成年女性的肥胖症显著相关；而DEHP和HMW代谢物与60岁及以上男性肥胖的比值比显著相关。
结论
我们发现尿邻苯二甲酸酯代谢物浓度与体重结果之间的关联存在年龄和性别差异。由于超重和肥胖的人脂肪量更多，他们可能储存更多邻苯二甲酸盐，从而导致排泄浓度更高，因此不能排除反向因果关系。
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