远曲小管
Distal convoluted tubule.
作者信息
Subramanya Arohan R, Ellison David H
机构信息
Departments of Medicine and Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania;
Departments of Medicine and Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.
出版信息
Clin J Am Soc Nephrol. 2014 Dec 5;9(12):2147-63. doi: 10.2215/CJN.05920613. Epub 2014 May 22.
Abstract
The distal convoluted tubule is the nephron segment that lies immediately downstream of the macula densa. Although short in length, the distal convoluted tubule plays a critical role in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic studies have greatly expanded our understanding of how the distal convoluted tubule regulates these processes at the molecular level. This article provides an update on the distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical practice.
摘要
远曲小管是紧位于致密斑下游的肾单位节段。尽管长度较短，但远曲小管在钠、钾和二价阳离子稳态中发挥着关键作用。最近的遗传学和生理学研究极大地扩展了我们对远曲小管如何在分子水平上调节这些过程的理解。本文提供了关于远曲小管的最新信息，重点介绍了与临床实践相关的概念和病理生理学。
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