B-1细胞作为抗原呈递细胞的概述。
An Overview of B-1 Cells as Antigen-Presenting Cells.
作者信息
Popi Ana F, Longo-Maugéri Ieda M, Mariano Mario
机构信息
Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo , São Paulo , Brazil.
出版信息
Front Immunol. 2016 Apr 11;7:138. doi: 10.3389/fimmu.2016.00138. eCollection 2016.
Abstract
The role of B cells as antigen-presenting cells (APCs) has been extensively studied, mainly in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 cells as APCs is beginning to be explored. Initially, it was described that B-1 cells are activated preferentially by T-independent antigens. However, some reports demonstrated that these cells are also involved in a T-dependent response. The aim of this review is to summarize information about the ability of B-1 cells to play a role as APCs and to briefly discuss the role of the BCR and toll-like receptor signals in this process. Furthermore, some characteristics of B-1 cells, such as natural IgM production and phagocytic ability, could interfere in the participation of these cells in the onset of an adaptive response.
摘要
B细胞作为抗原呈递细胞（APC）的作用已得到广泛研究，主要涉及记忆T细胞的激活。考虑到B细胞亚型，B-1细胞作为APC的作用正开始被探索。最初，有人描述B-1细胞优先被非T细胞依赖性抗原激活。然而，一些报告表明这些细胞也参与T细胞依赖性反应。本综述的目的是总结关于B-1细胞作为APC发挥作用的能力的信息，并简要讨论B细胞受体（BCR）和Toll样受体信号在此过程中的作用。此外，B-1细胞的一些特性，如天然IgM的产生和吞噬能力，可能会干扰这些细胞参与适应性反应的起始过程。
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本文引用的文献
1
B-1 phagocytes: the myeloid face of B-1 cells.
Ann N Y Acad Sci. 2015 Dec;1362:86-97. doi: 10.1111/nyas.12814. Epub 2015 Jul 6.
2
Role of B cell receptor signaling in IL-10 production by normal and malignant B-1 cells.
Ann N Y Acad Sci. 2015 Dec;1362(1):239-249. doi: 10.1111/nyas.12802. Epub 2015 Jun 11.
3
Modulation of Th1/Th2 immune responses by killed Propionibacterium acnes and its soluble polysaccharide fraction in a type I hypersensitivity murine model: induction of different activation status of antigen-presenting cells.
J Immunol Res. 2015;2015:132083. doi: 10.1155/2015/132083. Epub 2015 Apr 20.
4
B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules.
J Immunol. 2014 Mar 15;192(6):2699-714. doi: 10.4049/jimmunol.1301312. Epub 2014 Feb 14.
5
Atypical Response of B-1 Cells to BCR Ligation: A Speculative Model.
Front Immunol. 2013 Dec 16;4:457. doi: 10.3389/fimmu.2013.00457.
6
Peritoneal cavity B-1a cells promote peripheral CD4+ T-cell activation.
Eur J Immunol. 2013 Sep;43(9):2317-26. doi: 10.1002/eji.201343418. Epub 2013 Jul 3.
7
Multiple regulatory mechanisms control B-1 B cell activation.
Front Immunol. 2012 Dec 17;3:372. doi: 10.3389/fimmu.2012.00372. eCollection 2012.
8
Induction of Th17 cell differentiation by B-1 cells.
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9
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