儿童和成人多呼出气氮冲洗系统之间的一致性。
Agreement between multiple-breath nitrogen washout systems in children and adults.
作者信息
Poncin William, Singer Florian, Aubriot Anne-Sophie, Lebecque Patrick
机构信息
Cystic Fibrosis Unit, Cliniques Universitaires St Luc, Université de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium.
Division of Pediatric Pulmonology, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.
出版信息
J Cyst Fibros. 2017 Mar;16(2):258-266. doi: 10.1016/j.jcf.2016.11.004. Epub 2016 Dec 3.
BACKGROUND
Comparability of multiple breath washout (MBW) systems has been little explored. We assessed agreement in lung clearance index (LCI) from two similar, commercial nitrogen MBW setups in patients with Cystic Fibrosis (CF) and controls.
METHODS
The EasyOne Pro (NDD) and Exhalyzer D (EM) were randomly applied in 85 adults (34 with CF) and 97 children (47 with CF and normal forced expiratory volume in one second). We assessed differences between setups in LCI, lung volumes and breathing pattern and diagnostic performance for detecting abnormal lung function.
RESULTS
Compared to NDD, EM measured higher LCI, functional residual capacity and cumulative expired volume while respiratory rate was lower. Mean difference (limits of agreement) in LCI was 1.30 (-2.34 to 4.94). In CF, prevalence of abnormal LCI was greater in children and similar in adults using EM compared to NDD.
CONCLUSIONS
Agreement of MBW outcomes between setups is poor and explained by nitrogen measurement techniques and breathing pattern.
背景
多种呼气末冲洗（MBW）系统的可比性鲜有研究。我们评估了在囊性纤维化（CF）患者和对照组中，两种相似的商用氮气MBW装置所测得的肺清除指数（LCI）的一致性。
方法
将EasyOne Pro（NDD）和Exhalyzer D（EM）随机应用于85名成年人（34名CF患者）和97名儿童（47名CF患者且一秒用力呼气量正常）。我们评估了两种装置在LCI、肺容积和呼吸模式方面的差异，以及检测肺功能异常的诊断性能。
结果
与NDD相比，EM测得的LCI、功能残气量和累计呼出量更高，而呼吸频率更低。LCI的平均差异（一致性界限）为1.30（-2.34至4.94）。在CF患者中，与NDD相比，使用EM的儿童中LCI异常的患病率更高，而成年人中相似。
结论
不同装置之间MBW结果的一致性较差，这可由氮气测量技术和呼吸模式来解释。
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