癌症中的氧供应与代谢重编程
Oxygen availability and metabolic reprogramming in cancer.
作者信息
Xie Hong, Simon M Celeste
机构信息
From the Abramson Family Cancer Research Institute and.
Departments of Cancer Biology and.
出版信息
J Biol Chem. 2017 Oct 13;292(41):16825-16832. doi: 10.1074/jbc.R117.799973. Epub 2017 Aug 24.
Abstract
Hypoxia and dysregulated metabolism are defining features of solid tumors. How cancer cells adapt to low O has been illuminated by numerous studies, with "reprogrammed" metabolism being one of the most important mechanisms. This metabolic reprogramming not only promotes cancer cell plasticity, but also provides novel insights for treatment strategies. As the most studied O "sensor," hypoxia-inducible factor (HIF) is regarded as an important regulator of hypoxia-induced transcriptional responses. This minireview will summarize our current understanding of hypoxia-induced changes in cancer cell metabolism, with an initial focus on HIF-mediated effects, and will highlight how these metabolic alterations affect malignant phenotypes.
摘要
缺氧和代谢失调是实体瘤的典型特征。众多研究已阐明癌细胞如何适应低氧环境，其中“重编程”代谢是最重要的机制之一。这种代谢重编程不仅促进癌细胞的可塑性，还为治疗策略提供了新的见解。作为研究最多的氧“传感器”，缺氧诱导因子（HIF）被视为缺氧诱导转录反应的重要调节因子。本综述将总结我们目前对缺氧诱导癌细胞代谢变化的理解，首先关注HIF介导的效应，并将强调这些代谢改变如何影响恶性表型。
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