斋月禁食对糖尿病患者血糖控制及其他重要变量的影响。
Effect of ramadan fasting on glycemic control and other essential variables in diabetic patients.
作者信息
Bener Abdülbari, A Al-Hamaq Abdulla O A, Öztürk Mustafa, Çatan Funda, Haris Parvez I, Rajput Kaleem U, Ömer Abdülkadir
机构信息
Department of Biostatistics and Medical Informatics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, The University of Manchester, Manchester, UK; Department of Endocrinology, Regenerative and Resorative Medicine Research Centre, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Qatar Diabetic Association and Qatar Foundation for Research, Doha, Qatar.
出版信息
Ann Afr Med. 2018 Oct-Dec;17(4):196-202. doi: 10.4103/aam.aam_63_17.
BACKGROUND
Fasting during the holy month of Ramadan is a religious obligation for all Muslims who represent 1.8 billion of the world population (24%). This study explores the effect of Ramadan fasting on the blood glucose, glycated hemoglobin (HbA1c), lipid profile, sleeping quality, and essential lifestyle parameters and also explores the safety of fasting for a whole month among diabetic patients.
AIM
The aim of the present study was to assess the impact of Ramadan fasting on the blood glucose, HbA1c, lipid profile, sleeping quality, and lifestyle parameters among patients with type 2 diabetes mellitus (T2DM) in Turkey.
SUBJECTS AND METHODS
A total of 1780 diabetic patients were approached, and 1246 (70%) participated in this cross-sectional study carried out during the period from May 27, 2017, to June 24, 2017. Data analysis comprised sociodemographic features, lifestyle habits, blood pressure measurements, serum lipid profiles, serum calcium, Vitamin D 25-hydroxy, uric acid, and HbA1c at before 4 weeks and after 12 weeks from Ramadan.
RESULTS
Out of 1246 patients, 593 (47.6%) were male and 653 (52.4%) were female. The mean ± standard deviation age of the patients was 50.39 ± 15.3 years. Males were significantly older than females (51.53 ± 12.56 vs. 49.26 ± 14.4; P = 0.003, respectively). Significant differences were found in Vitamin D, blood glucose, HbA1c level, creatinine, bilirubin, albumin, total cholesterol, triglycerides, high-density lipoprotein-cholesterol (female), low-density lipoprotein-cholesterol (male), uric acid, and systolic and diastolic blood pressure after and before the holy month of Ramadan (P < 0.05 for each). HbA1c (P < 0.001), physical activity (P < 0.001), hours of sleeping (P < 0.001), systolic blood pressure (BP) (mmHg) (P = 0.007), BMI (P = 0.016), diastolic BP (mmHg) (P = 0.018), family history (P = 0.021), and smoking (P = 0.045) were identified as significantly associated with Ramadan fasting as contributing factors.
CONCLUSION
In one of the largest studies of its kind, we show that Ramadan fasting has positive effects on T2DM patients as it reduces their blood pressure, blood glucose, HbA1C, and BMI. Furthermore, there are improvements in the duration of sleep and physical activity, the role of Ramadan fasting in diabetes therapy has been confirmed.
背景
在斋月期间禁食是所有穆斯林的宗教义务，全球有18亿穆斯林，占世界人口的24%。本研究探讨斋月禁食对血糖、糖化血红蛋白（HbA1c）、血脂谱、睡眠质量和基本生活方式参数的影响，同时探讨糖尿病患者全月禁食的安全性。
目的
本研究的目的是评估斋月禁食对土耳其2型糖尿病（T2DM）患者的血糖、HbA1c、血脂谱、睡眠质量和生活方式参数的影响。
对象与方法
共纳入1780例糖尿病患者，1246例（70%）参与了这项于2017年5月27日至2017年6月24日期间进行的横断面研究。数据分析包括社会人口学特征、生活习惯、血压测量、血清脂质谱、血清钙、25-羟维生素D、尿酸以及斋月前4周和后12周的HbA1c。
结果
1246例患者中，593例（47.6%）为男性，653例（52.4%）为女性。患者的平均年龄±标准差为50.39±15.3岁。男性明显比女性年龄大（分别为51.53±12.56岁和49.26±14.4岁；P=0.003）。在斋月前后，维生素D、血糖、HbA1c水平、肌酐、胆红素、白蛋白、总胆固醇、甘油三酯、高密度脂蛋白胆固醇（女性）、低密度脂蛋白胆固醇（男性）、尿酸以及收缩压和舒张压存在显著差异（每项P<0.05）。HbA1c（P<0.001）、身体活动（P<0.001）、睡眠时间（P<0.001）、收缩压（BP）（mmHg）（P=0.007）、BMI（P=0.016）、舒张压BP（mmHg）（P=0.018）、家族史（P=0.021）和吸烟（P=0.045）被确定为与斋月禁食显著相关的影响因素。
结论
在同类规模最大的研究之一中，我们表明斋月禁食对T2DM患者有积极影响，因为它降低了他们的血压、血糖、HbA1C和BMI。此外，睡眠时长和身体活动也有所改善，斋月禁食在糖尿病治疗中的作用得到了证实。
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