University of Pennsylvania School of Medicine, Philadelphia.
Boston University School of Medicine, Boston, Massachusetts.
Arthritis Rheumatol. 2020 Feb;72(2):220-233. doi: 10.1002/art.41142. Epub 2020 Jan 6.
To develop an evidence-based guideline for the comprehensive management of osteoarthritis (OA) as a collaboration between the American College of Rheumatology (ACR) and the Arthritis Foundation, updating the 2012 ACR recommendations for the management of hand, hip, and knee OA.
We identified clinically relevant population, intervention, comparator, outcomes questions and critical outcomes in OA. A Literature Review Team performed a systematic literature review to summarize evidence supporting the benefits and harms of available educational, behavioral, psychosocial, physical, mind-body, and pharmacologic therapies for OA. Grading of Recommendations Assessment, Development and Evaluation methodology was used to rate the quality of the evidence. A Voting Panel, including rheumatologists, an internist, physical and occupational therapists, and patients, achieved consensus on the recommendations.
Based on the available evidence, either strong or conditional recommendations were made for or against the approaches evaluated. Strong recommendations were made for exercise, weight loss in patients with knee and/or hip OA who are overweight or obese, self-efficacy and self-management programs, tai chi, cane use, hand orthoses for first carpometacarpal (CMC) joint OA, tibiofemoral bracing for tibiofemoral knee OA, topical nonsteroidal antiinflammatory drugs (NSAIDs) for knee OA, oral NSAIDs, and intraarticular glucocorticoid injections for knee OA. Conditional recommendations were made for balance exercises, yoga, cognitive behavioral therapy, kinesiotaping for first CMC OA, orthoses for hand joints other than the first CMC joint, patellofemoral bracing for patellofemoral knee OA, acupuncture, thermal modalities, radiofrequency ablation for knee OA, topical NSAIDs, intraarticular steroid injections and chondroitin sulfate for hand OA, topical capsaicin for knee OA, acetaminophen, duloxetine, and tramadol.
This guideline provides direction for clinicians and patients making treatment decisions for the management of OA. Clinicians and patients should engage in shared decision-making that accounts for patients' values, preferences, and comorbidities. These recommendations should not be used to limit or deny access to therapies.
作为美国风湿病学会(ACR)与关节炎基金会的合作项目,制定一份基于循证医学的骨关节炎(OA)综合管理指南,对 2012 年 ACR 手部、髋关节和膝关节 OA 管理建议进行更新。
我们确定了与 OA 相关的临床问题,包括干预措施、比较方法和结局。文献综述团队对现有 OA 教育、行为、心理社会、物理、身心和药物治疗的有效性和安全性进行了系统评价。采用推荐分级的评估、制定与评价(GRADE)方法评估证据质量。由风湿病学家、内科医生、理疗师和患者组成的投票小组对建议达成共识。
根据现有证据,对评估方法提出了或强或弱的推荐建议。对于运动、超重或肥胖的膝和/或髋关节 OA 患者的减重、自我效能和自我管理计划、太极、手杖使用、第一腕掌关节(CMC)OA 的手部支具、治疗膝关节内翻型 OA 的胫股关节支具、治疗膝关节 OA 的局部非甾体抗炎药(NSAIDs)、口服 NSAIDs、膝关节 OA 的关节内糖皮质激素注射等方法,给出了强烈的推荐建议。对于平衡练习、瑜伽、认知行为疗法、第一 CMC OA 的运动贴扎、除第一 CMC 关节以外的手部关节支具、髌股关节 OA 的髌股关节支具、针灸、温热疗法、膝关节 OA 的射频消融、手部 OA 的局部皮质类固醇注射和硫酸软骨素、膝关节 OA 的辣椒素贴剂、对乙酰氨基酚、度洛西汀和曲马多等方法,给出了条件性的推荐建议。
本指南为临床医生和患者在 OA 管理治疗决策方面提供了指导。临床医生和患者应进行共同决策,考虑患者的价值观、偏好和合并症。这些建议不应被用来限制或拒绝治疗方法的应用。