二氮烯二醇盐的药理作用、作用机制及应用前景的研究进展
Recent Developments in Pharmacological Effect, Mechanism and Application Prospect of Diazeniumdiolates.
作者信息
Li Bin, Ming Yue, Liu Yao, Xing Haiyan, Fu Ruoqiu, Li Ziwei, Ni Rui, Li Li, Duan Dongyu, Xu Jing, Li Chen, Xiang Mingfeng, Song Hongyu, Chen Jianhong
机构信息
Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, China.
出版信息
Front Pharmacol. 2020 Jun 23;11:923. doi: 10.3389/fphar.2020.00923. eCollection 2020.
Abstract
Nitric oxide (NO) is a simple structured and unstable free radical molecule, which participates in the regulation of many pathophysiological processes. It functions both as a second messenger and as an endogenous neurotransmitter. Diazeniumdiolates (NONOates) are a series of compounds containing the functional parent nuclear structure of [N(O)NO], which are the most widely studied NO donors. NONOates are unstable and easy to release NO in physiological conditions. The biomedical applications and drug development of NO donor have attracted the scientists' attention in recent years. In this review, recent advances in NONOates research are highlighted in terms of chemical structures, molecular characteristics, pharmacological effects, and biomedical application prospects.
摘要
一氧化氮（NO）是一种结构简单且不稳定的自由基分子，它参与许多病理生理过程的调节。它既作为第二信使又作为内源性神经递质发挥作用。二氮烯二醇盐（NONOates）是一系列含有[N(O)NO]功能母体核结构的化合物，是研究最为广泛的NO供体。NONOates不稳定，在生理条件下易于释放NO。近年来，NO供体的生物医学应用和药物开发引起了科学家们的关注。在这篇综述中，将从化学结构、分子特征、药理作用和生物医学应用前景等方面重点介绍NONOates研究的最新进展。
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本文引用的文献
1
Nitric Oxide-Loaded Antimicrobial Polymer for the Synergistic Eradication of Bacterial Biofilm.
ACS Macro Lett. 2018 May 15;7(5):592-597. doi: 10.1021/acsmacrolett.8b00190. Epub 2018 May 4.
2
Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A.
Molecules. 2019 Oct 16;24(20):3722. doi: 10.3390/molecules24203722.
3
Insights Into Nitric Oxide Modulated Quorum Sensing Pathways.
Front Microbiol. 2019 Sep 24;10:2174. doi: 10.3389/fmicb.2019.02174. eCollection 2019.
4
Nitric Oxide-Mediated Enhancement and Reversal of Resistance of Anticancer Therapies.
Antioxidants (Basel). 2019 Sep 17;8(9):407. doi: 10.3390/antiox8090407.
5
Targeting nitric oxide as a key modulator of sepsis, arthritis and pain.
Nitric Oxide. 2019 Aug 1;89:32-40. doi: 10.1016/j.niox.2019.04.011. Epub 2019 Apr 30.
6
A polyethylenimine-based diazeniumdiolate nitric oxide donor accelerates wound healing.
Biomater Sci. 2019 Mar 26;7(4):1607-1616. doi: 10.1039/c8bm01519h.
7
Combination Therapy with DETA/NO and Clopidogrel Inhibits Metastasis in Murine Mammary Gland Cancer Models via Improved Vasoprotection.
Mol Pharm. 2018 Nov 5;15(11):5277-5290. doi: 10.1021/acs.molpharmaceut.8b00781. Epub 2018 Oct 4.
8
Don't just say no: Differential pathways and pharmacological responses to diverse nitric oxide donors.
Biochem Pharmacol. 2018 Oct;156:1-9. doi: 10.1016/j.bcp.2018.08.002. Epub 2018 Aug 3.
9
Recent Developments in Drug Design of NO-donor Hybrid Compounds.
Mini Rev Med Chem. 2018;18(14):1175-1198. doi: 10.2174/1389557518666180416150005.
10
Cross-talk between endogenous HS and NO accounts for vascular protective activity of the metal-nonoate Zn(PipNONO)Cl.
Biochem Pharmacol. 2018 Jun;152:143-152. doi: 10.1016/j.bcp.2018.03.025. Epub 2018 Mar 26.
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