线粒体 Miro GTPases 协调线粒体和过氧化物酶体的动态变化。
Mitochondrial Miro GTPases coordinate mitochondrial and peroxisomal dynamics.
机构信息
Departments of Neuroscience and Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA.
出版信息
Small GTPases. 2021 Sep-Nov;12(5-6):372-398. doi: 10.1080/21541248.2020.1843957. Epub 2020 Nov 12.
Abstract
Mitochondria and peroxisomes are highly dynamic, multifunctional organelles. Both perform key roles for cellular physiology and homoeostasis by mediating bioenergetics, biosynthesis, and/or signalling. To support cellular function, they must be properly distributed, of proper size, and be able to interact with other organelles. Accumulating evidence suggests that the small atypical GTPase Miro provides a central signalling node to coordinate mitochondrial as well as peroxisomal dynamics. In this review, I summarize our current understanding of Miro-dependent functions and molecular mechanisms underlying the proper distribution, size and function of mitochondria and peroxisomes.
摘要
线粒体和过氧化物酶体是高度动态的多功能细胞器。它们通过介导生物能量学、生物合成和/或信号转导，对细胞生理学和内稳态起着关键作用。为了支持细胞功能，它们必须正确分布，具有适当的大小，并能够与其他细胞器相互作用。越来越多的证据表明，小的非典型 GTP 酶 Miro 提供了一个中央信号节点，以协调线粒体和过氧化物酶体的动力学。在这篇综述中，我总结了我们目前对 Miro 依赖性功能以及线粒体和过氧化物酶体正确分布、大小和功能的分子机制的理解。
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本文引用的文献
1
Miro2 supplies a platform for Parkin translocation to damaged mitochondria.
Sci Bull (Beijing). 2019 Jun 15;64(11):730-747. doi: 10.1016/j.scib.2019.04.033. Epub 2019 May 2.
2
Mitochondrial Diseases: A Diagnostic Revolution.
Trends Genet. 2020 Sep;36(9):702-717. doi: 10.1016/j.tig.2020.06.009. Epub 2020 Jul 13.
3
DISC1 Regulates Mitochondrial Trafficking in a Miro1-GTP-Dependent Manner.
Front Cell Dev Biol. 2020 Jun 19;8:449. doi: 10.3389/fcell.2020.00449. eCollection 2020.
4
Miro2 tethers the ER to mitochondria to promote mitochondrial fusion in tobacco leaf epidermal cells.
Commun Biol. 2020 Apr 3;3(1):161. doi: 10.1038/s42003-020-0872-x.
5
Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling.
Nat Commun. 2020 Feb 26;11(1):1050. doi: 10.1038/s41467-020-14885-x.
6
Peroxisomal fission is modulated by the mitochondrial Rho-GTPases, Miro1 and Miro2.
EMBO Rep. 2020 Feb 5;21(2):e49865. doi: 10.15252/embr.201949865. Epub 2020 Jan 2.
7
Mitochondrial Dynamics and Its Involvement in Disease.
Annu Rev Pathol. 2020 Jan 24;15:235-259. doi: 10.1146/annurev-pathmechdis-012419-032711. Epub 2019 Oct 4.
8
Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models.
Cell Metab. 2019 Dec 3;30(6):1131-1140.e7. doi: 10.1016/j.cmet.2019.08.023. Epub 2019 Sep 26.
9
Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery.
Nat Commun. 2019 Sep 27;10(1):4399. doi: 10.1038/s41467-019-12382-4.
10
Axonal transport and neurological disease.
Nat Rev Neurol. 2019 Dec;15(12):691-703. doi: 10.1038/s41582-019-0257-2. Epub 2019 Sep 26.
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