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针对 COVID-19 的口罩有效性评估综述

An evidence review of face masks against COVID-19.

机构信息

fast.ai, San Francisco, CA 94105;

Data Institute, University of San Francisco, San Francisco, CA 94105.

出版信息

Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). doi: 10.1073/pnas.2014564118.

Abstract

The science around the use of masks by the public to impede COVID-19 transmission is advancing rapidly. In this narrative review, we develop an analytical framework to examine mask usage, synthesizing the relevant literature to inform multiple areas: population impact, transmission characteristics, source control, wearer protection, sociological considerations, and implementation considerations. A primary route of transmission of COVID-19 is via respiratory particles, and it is known to be transmissible from presymptomatic, paucisymptomatic, and asymptomatic individuals. Reducing disease spread requires two things: limiting contacts of infected individuals via physical distancing and other measures and reducing the transmission probability per contact. The preponderance of evidence indicates that mask wearing reduces transmissibility per contact by reducing transmission of infected respiratory particles in both laboratory and clinical contexts. Public mask wearing is most effective at reducing spread of the virus when compliance is high. Given the current shortages of medical masks, we recommend the adoption of public cloth mask wearing, as an effective form of source control, in conjunction with existing hygiene, distancing, and contact tracing strategies. Because many respiratory particles become smaller due to evaporation, we recommend increasing focus on a previously overlooked aspect of mask usage: mask wearing by infectious people ("source control") with benefits at the population level, rather than only mask wearing by susceptible people, such as health care workers, with focus on individual outcomes. We recommend that public officials and governments strongly encourage the use of widespread face masks in public, including the use of appropriate regulation.

摘要

公众使用口罩来阻止 COVID-19 传播的科学研究正在迅速发展。在这篇叙述性评论中,我们构建了一个分析框架来检查口罩使用情况,综合相关文献,以告知多个领域:人群影响、传播特征、源头控制、佩戴者保护、社会学考虑因素和实施考虑因素。COVID-19 的主要传播途径是通过呼吸道飞沫,已知其可从无症状、轻症和无症状个体传播。减少疾病传播需要两件事:通过物理距离和其他措施限制感染个体的接触,以及降低每次接触的传播概率。大量证据表明,口罩佩戴通过减少实验室和临床环境中感染呼吸道飞沫的传播,降低了每次接触的传染性。当公众遵守率较高时,公众佩戴口罩对减少病毒传播最有效。鉴于目前医用口罩短缺,我们建议采用公众佩戴布制口罩,作为一种有效的源头控制措施,结合现有的卫生、距离和接触者追踪策略。由于许多呼吸道飞沫由于蒸发而变小,我们建议更加关注口罩使用的一个以前被忽视的方面:感染人群(“源头控制”)佩戴口罩,这对人群水平有好处,而不仅仅是易感人群(如医护人员)佩戴口罩,重点是个人结果。我们建议政府官员和政府大力鼓励公众在公共场所广泛使用口罩,包括适当的监管。

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