膳食摄入量和家庭暴露作为预测青少年尿液中高分子量邻苯二甲酸酯和双酚 A 浓度的因素。
Dietary intake and household exposures as predictors of urinary concentrations of high molecular weight phthalates and bisphenol A in a cohort of adolescents.
机构信息
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
出版信息
J Expo Sci Environ Epidemiol. 2022 Jan;32(1):37-47. doi: 10.1038/s41370-021-00305-9. Epub 2021 Feb 22.
BACKGROUND
Phthalates and bisphenol A (BPA) are endocrine disrupting chemicals used in consumer products, building materials, and food processing and packaging materials. They are associated with adverse health outcomes, especially when exposure occurs during heightened windows of susceptibility.
OBJECTIVE
We evaluated the relationship between housing and dietary characteristics and the concentration of several high-molecular-weight (HMW) phthalate metabolites and BPA in a cohort of Latina adolescents.
METHODS
We collected information on recent food consumption and housing characteristics and quantified the concentration of HMW phthalate and BPA metabolites in urine collected at two different time points. We used generalized estimating equations (GEE) to assess predictors of each metabolite.
RESULTS
No significant associations were observed between housing and dietary characteristics and metabolites of di(2-ethylhexyl) phthalate (DEHP) or BPA. In contrast, higher urinary monobenzyl phthalate (MBzP) concentration was associated with living in a home with vinyl or linoleum flooring (66.7% change, p-value <0.01), while higher urinary mono(3-carboxypropyl) phthalate (MCPP) concentration was associated with recent consumption of coffee (47.2% change, p-value <0.01), and fast food (30.3% change, p-value <0.05).
SIGNIFICANCE
These findings may be useful in targeting interventions that reduce phthalate uptake in young adults.
背景
邻苯二甲酸酯和双酚 A（BPA）是用于消费产品、建筑材料以及食品加工和包装材料的内分泌干扰化学物质。它们与不良健康结果有关，尤其是在易感性增加的窗口期暴露时。
目的
我们评估了住房和饮食特征与几种高分子量（HMW）邻苯二甲酸酯代谢物和 BPA 浓度在拉丁裔青少年队列中的关系。
方法
我们收集了近期食物消费和住房特征的信息，并在两个不同时间点采集尿液以定量 HMW 邻苯二甲酸酯和 BPA 代谢物的浓度。我们使用广义估计方程（GEE）评估每种代谢物的预测因素。
结果
未观察到住房和饮食特征与邻苯二甲酸二（2-乙基己基）酯（DEHP）或 BPA 代谢物之间存在显著关联。相比之下，尿液中单苄基邻苯二甲酸酯（MBzP）浓度较高与居住在乙烯基或亚麻油毡地板的家中有关（66.7%的变化，p 值 <0.01），而尿液中单（3-羧基丙基）邻苯二甲酸酯（MCPP）浓度较高与近期摄入咖啡有关（47.2%的变化，p 值 <0.01）和快餐（30.3%的变化，p 值 <0.05）。
意义
这些发现可能有助于针对减少年轻人邻苯二甲酸酯摄取的干预措施。
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