从裸子植物中提取的天然植物化学物质在癌症的预防和治疗中的应用。
Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers.
机构信息
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 15731, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz 15731, Iran.
出版信息
Int J Mol Sci. 2021 Jun 21;22(12):6636. doi: 10.3390/ijms22126636.
The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Gymnosperms have great potential for further study for the discovery of new anticancer compounds. This review aims to provide a rational understanding and the latest developments in potential anticancer compounds derived from gymnosperms.
全球各种类型的癌症发病率正在上升。为了降低癌症化疗的严重副作用，人们一直在考虑使用天然衍生化合物来治疗癌症。裸子植物是一类在全球范围内广泛存在的植物，它们在传统上被用于治疗应用。紫杉醇是一种从裸子植物中提取的商业上可用的抗癌药物。其他具有抗癌活性的天然化合物，如松属素和松属素，是从松心材中提取的，而碧萝芷和恩杂醇则是从松树皮中提取的。裸子植物在发现新的抗癌化合物方面具有很大的研究潜力。本综述旨在为理解和开发裸子植物衍生的潜在抗癌化合物提供一个合理的最新进展。
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