免疫耗竭：如何使一个不同的概念运作？
Immunological exhaustion: How to make a disparate concept operational?
机构信息
ImmunoConcept, CNRS & University of Bordeaux, Bordeaux, France.
出版信息
PLoS Pathog. 2021 Sep 23;17(9):e1009892. doi: 10.1371/journal.ppat.1009892. eCollection 2021 Sep.
Abstract
In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
摘要
在这篇文章中，我们表明，3 种不同的免疫衰竭方法同时存在，且它们只有部分重叠，这可能会产生一些误解。通过对病毒感染到癌症等案例的研究，我们提出，为了实验和治疗的目的，澄清这些方法及其相互关系至关重要，以使衰竭的概念真正发挥作用。
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