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IntAct 数据库:高效访问细粒度分子相互作用数据。

The IntAct database: efficient access to fine-grained molecular interaction data.

机构信息

European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton, Cambridgeshire CB10 1SD, UK.

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.

出版信息

Nucleic Acids Res. 2022 Jan 7;50(D1):D648-D653. doi: 10.1093/nar/gkab1006.

Abstract

The IntAct molecular interaction database (https://www.ebi.ac.uk/intact) is a curated resource of molecular interactions, derived from the scientific literature and from direct data depositions. As of August 2021, IntAct provides more than one million binary interactions, curated by twelve global partners of the International Molecular Exchange consortium, for which the IntAct database provides a shared curation and dissemination platform. The IMEx curation policy has always emphasised a fine-grained data and curation model, aiming to capture the relevant experimental detail essential for the interpretation of the provided molecular interaction data. Here, we present recent curation focus and progress, as well as a completely redeveloped website which presents IntAct data in a much more user-friendly and detailed way.

摘要

IntAct 分子相互作用数据库(https://www.ebi.ac.uk/intact)是一个经过精心整理的分子相互作用资源,来源于科学文献和直接的数据提交。截至 2021 年 8 月,IntAct 提供了超过 100 万个二元相互作用,由国际分子交换联盟的十二个全球合作伙伴进行整理,IntAct 数据库为其提供了一个共享的整理和传播平台。IMEx 的整理政策一直强调精细的数据和整理模型,旨在捕捉提供的分子相互作用数据解释所必需的相关实验细节。在这里,我们介绍最近的整理重点和进展,以及一个完全重新开发的网站,以更用户友好和详细的方式呈现 IntAct 数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5876/8728211/d9c8e4321042/gkab1006fig1.jpg

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