MAFB 通过 IGFBP6 促进食管鳞癌细胞的恶性表型。

MAFB promotes the malignant phenotypes by IGFBP6 in esophageal squamous cell carcinomas.

机构信息

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

出版信息

Exp Cell Res. 2022 Jul 1;416(1):113158. doi: 10.1016/j.yexcr.2022.113158. Epub 2022 Apr 14.

DOI:10.1016/j.yexcr.2022.113158

PMID:35430273

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant diseases in the world. Although the somatic alterations have been fully identified, there are still no targeted drugs at present. Our previous studies revealed that loss of grand H3K27me3 domains mediated transcriptional activation of a series of genes in ESCC. Among them, we focus on the investigation of MAFB, as its high expression is associated with a poor prognosis in ESCC. Functional assays show that knockdown of MAFB significantly suppresses cell growth, migration and invasion. Mechanistic investigation demonstrates that MAFB exerts its function by upregulating IGFBP6. Our findings suggest that MAFB may play a tumor-promoting role and may act as a potential therapeutic target for ESCC.

摘要

食管鳞状细胞癌（ESCC）是世界上最常见的恶性疾病之一。尽管已经充分鉴定了体细胞改变，但目前仍然没有靶向药物。我们之前的研究表明，大 H3K27me3 结构域的缺失介导了 ESCC 中一系列基因的转录激活。其中，我们专注于 MAFB 的研究，因为其高表达与 ESCC 的不良预后相关。功能分析表明，MAFB 的敲低显著抑制细胞生长、迁移和侵袭。机制研究表明，MAFB 通过上调 IGFBP6 发挥作用。我们的研究结果表明，MAFB 可能发挥肿瘤促进作用，并可能成为 ESCC 的潜在治疗靶点。