干扰素-γ信号基因的突变使肿瘤对免疫检查点阻断敏感。
Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade.
作者信息
Song Eric, Chow Ryan D
机构信息
Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Department of Ophthalmology, Yale University School of Medicine, New Haven, CT, USA.
Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
出版信息
Cancer Cell. 2023 Apr 10;41(4):651-652. doi: 10.1016/j.ccell.2023.02.013. Epub 2023 Mar 16.
Song and Chow demonstrate that while tumor-intrinsic mutations in the IFN-γ signaling pathway confer immune resistance across in vitro co-culture systems, such alterations associate with enhanced anti-tumor immunity in vivo and improved responsiveness to immune checkpoint blockade therapy in patients with cancer.
宋和周证明，虽然干扰素-γ信号通路中的肿瘤内在突变在体外共培养系统中赋予免疫抗性，但这种改变与体内增强的抗肿瘤免疫力以及癌症患者对免疫检查点阻断疗法的反应性改善相关。
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