核苷酸代谢在癌症中的新兴作用。
Emerging roles of nucleotide metabolism in cancer.
机构信息
Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Trends Cancer. 2023 Aug;9(8):624-635. doi: 10.1016/j.trecan.2023.04.008. Epub 2023 May 10.
Nucleotides are substrates for multiple anabolic pathways, most notably DNA and RNA synthesis. Since nucleotide synthesis inhibitors began to be used for cancer therapy in the 1950s, our understanding of how nucleotides function in tumor cells has evolved, prompting a resurgence of interest in targeting nucleotide metabolism for cancer therapy. In this review, we discuss recent advances that challenge the idea that nucleotides are mere building blocks for the genome and transcriptome and highlight ways that these metabolites support oncogenic signaling, stress resistance, and energy homeostasis in tumor cells. These findings point to a rich network of processes sustained by aberrant nucleotide metabolism in cancer and reveal new therapeutic opportunities.
核苷酸是多种合成代谢途径的底物，其中最重要的是 DNA 和 RNA 的合成。自 20 世纪 50 年代核苷酸合成抑制剂开始用于癌症治疗以来，我们对核苷酸在肿瘤细胞中的功能的认识不断发展，这促使人们重新关注以核苷酸代谢为靶点的癌症治疗。在这篇综述中，我们讨论了最近的进展，这些进展挑战了核苷酸仅仅是基因组和转录组的构建模块的观点，并强调了这些代谢物如何支持肿瘤细胞中的致癌信号、应激抵抗和能量平衡。这些发现指出了癌症中异常核苷酸代谢所维持的丰富的过程网络，并揭示了新的治疗机会。
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