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代谢疾病与健康老龄化:识别环境和行为风险因素,促进公共健康。

Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health.

机构信息

Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, China.

Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, China.

出版信息

Front Public Health. 2023 Oct 13;11:1253506. doi: 10.3389/fpubh.2023.1253506. eCollection 2023.

Abstract

Aging is a progressive and irreversible pathophysiological process that manifests as the decline in tissue and cellular functions, along with a significant increase in the risk of various aging-related diseases, including metabolic diseases. While advances in modern medicine have significantly promoted human health and extended human lifespan, metabolic diseases such as obesity and type 2 diabetes among the older adults pose a major challenge to global public health as societies age. Therefore, understanding the complex interaction between risk factors and metabolic diseases is crucial for promoting well-being and healthy aging. This review article explores the environmental and behavioral risk factors associated with metabolic diseases and their impact on healthy aging. The environment, including an obesogenic environment and exposure to environmental toxins, is strongly correlated with the rising prevalence of obesity and its comorbidities. Behavioral factors, such as diet, physical activity, smoking, alcohol consumption, and sleep patterns, significantly influence the risk of metabolic diseases throughout aging. Public health interventions targeting modifiable risk factors can effectively promote healthier lifestyles and prevent metabolic diseases. Collaboration between government agencies, healthcare providers and community organizations is essential for implementing these interventions and creating supportive environments that foster healthy aging.

摘要

衰老是一个渐进的、不可逆转的病理生理过程,表现为组织和细胞功能的下降,以及各种与衰老相关的疾病风险显著增加,包括代谢性疾病。尽管现代医学的进步极大地促进了人类的健康并延长了人类的寿命,但老年人中肥胖和 2 型糖尿病等代谢性疾病给全球公共卫生带来了重大挑战,因为社会正在老龄化。因此,了解风险因素与代谢性疾病之间的复杂相互作用对于促进健康老龄化至关重要。本文综述了与代谢性疾病相关的环境和行为风险因素及其对健康老龄化的影响。环境因素,包括致肥胖环境和环境毒素暴露,与肥胖及其合并症的患病率上升密切相关。行为因素,如饮食、身体活动、吸烟、饮酒和睡眠模式,在整个衰老过程中显著影响代谢性疾病的风险。针对可改变风险因素的公共卫生干预措施可以有效地促进更健康的生活方式,预防代谢性疾病。政府机构、医疗保健提供者和社区组织之间的合作对于实施这些干预措施和创造支持健康老龄化的环境至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2041/10603303/ede9c9275904/fpubh-11-1253506-g001.jpg

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