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CD24在癌症之外的惊人魔力。

Surprising magic of CD24 beyond cancer.

作者信息

Wang He, Shi Peng, Shi Xinyu, Lv Yaqing, Xie Hongwei, Zhao Hai

机构信息

Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, China.

Department of Emergency Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.

出版信息

Front Immunol. 2024 Jan 19;14:1334922. doi: 10.3389/fimmu.2023.1334922. eCollection 2023.

Abstract

CD24 has emerged as a molecule of significant interest beyond the oncological arena. Recent studies have unveiled its surprising and diverse roles in various biological processes and diseases. This review encapsulates the expanding spectrum of CD24 functions, delving into its involvement in immune regulation, cancer immune microenvironment, and its potential as a therapeutic target in autoimmune diseases and beyond. The 'magic' of CD24, once solely attributed to cancer, now inspires a new paradigm in understanding its multifunctionality in human health and disease, offering exciting prospects for medical advancements.

摘要

CD24已成为肿瘤学领域之外备受关注的一种分子。最近的研究揭示了它在各种生物过程和疾病中令人惊讶且多样的作用。这篇综述概括了CD24功能不断扩展的范围,深入探讨了它在免疫调节、癌症免疫微环境中的作用,以及它作为自身免疫性疾病及其他疾病治疗靶点的潜力。CD24的“神奇之处”,曾一度仅与癌症相关,如今在理解其在人类健康和疾病中的多功能性方面激发了一种新的范式,为医学进步提供了令人兴奋的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4f6/10834733/dd59c9ea01b0/fimmu-14-1334922-g001.jpg

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