男性30种癌症的负担：基于人群估计的2022年全球统计数据及2050年预测

Burden of 30 cancers among men: Global statistics in 2022 and projections for 2050 using population-based estimates.

作者信息

Bizuayehu Habtamu Mellie, Dadi Abel F, Ahmed Kedir Y, Tegegne Teketo Kassaw, Hassen Tahir Ahmed, Kibret Getiye Dejenu, Ketema Daniel Bekele, Bore Meless G, Thapa Subash, Odo Daniel Bogale, Kassa Zemenu Y, Shifti Desalegn Markos, Amsalu Erkihun, Sarich Peter, Venchiarutti Rebecca L, Melaku Yohannes Adama, Kibret Kelemu Tilahun, Habte Aklilu, Mefsin Yonatan M, Seid Abdulbasit, Belachew Sewunet Admasu

机构信息

School of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

出版信息

Cancer. 2024 Nov 1;130(21):3708-3723. doi: 10.1002/cncr.35458. Epub 2024 Aug 12.

DOI:10.1002/cncr.35458

PMID:39129420

Abstract

BACKGROUND

Men exhibit higher prevalence of modifiable risk factors, such as smoking and alcohol consumption, leading to greater cancer incidence and lower survival rates. Comprehensive evidence on global cancer burden among men, including disparities by age group and country, is sparse. To address this, the authors analyzed 30 cancer types among men in 2022, with projections estimated for 2050.

METHODS

The 2022 GLOBOCAN estimates were used to describe cancer statistics for men in 185 countries/territories worldwide. Mortality-to-incidence ratios (MIRs) were calculated by dividing age-standardized mortality rates by incidence rates.

RESULTS

In 2022, a high MIR (indicating poor survival) was observed among older men (aged 65 years and older; 61%) for rare cancer types (pancreatic cancer, 91%) and in countries with low a Human Development Index (HDI; 74%). Between 2022 and 2050, cancer cases are projected to increase from 10.3 million to 19 million (≥84%). Deaths are projected to increase from 5.4 million to 10.5 million (≥93%), with a greater than two-fold increase among men aged 65 years and older (≥117%) and for low-HDI and medium-HDI countries/territories (≥160%). Cancer cases and deaths are projected to increase among working-age groups (≥39%) and very-high-HDI countries/territories (≥50%).

CONCLUSIONS

Substantial disparities in cancer cases and deaths were observed among men in 2022, and these are projected to widen by 2050. Strengthening health infrastructure, enhancing workforce quality and access, fostering national and international collaborations, and promoting universal health coverage are crucial to reducing cancer disparities and ensuring cancer equity among men globally.

摘要

背景

男性中可改变的风险因素，如吸烟和饮酒，患病率较高，这导致更高的癌症发病率和更低的生存率。关于全球男性癌症负担的全面证据，包括按年龄组和国家划分的差异，较为稀少。为解决这一问题，作者分析了2022年男性中的30种癌症类型，并对2050年进行了预测估计。

方法

2022年全球癌症负担（GLOBOCAN）估计数用于描述全球185个国家/地区男性的癌症统计数据。通过将年龄标准化死亡率除以发病率来计算死亡率与发病率之比（MIRs）。

结果

2022年，在老年男性（65岁及以上；61%）中，罕见癌症类型（胰腺癌，91%）以及人类发展指数（HDI）较低的国家（74%）中观察到高MIR（表明生存率低）。在2022年至2050年期间，癌症病例预计将从1030万增加到1900万（增加≥84%）。死亡人数预计将从540万增加到1050万（增加≥93%），65岁及以上男性（增加≥117%）以及低HDI和中等HDI国家/地区（增加≥160%）的增幅超过两倍。预计工作年龄组（增加≥39%）和人类发展指数非常高的国家/地区（增加≥50%）的癌症病例和死亡人数也将增加。