探索天然产物和植物提取物在芽殖酵母中的抗衰老潜力：综述
Exploring the anti-aging potential of natural products and plant extracts in budding yeast : A review.
作者信息
Alugoju Phaniendra, Palanisamy Chella Perumal, Anthikapalli Naga Venkata Anusha, Jayaraman Selvaraj, Prasanskulab Anchalee, Chuchawankul Siriporn, Dyavaiah Madhu, Tencomnao Tewin
机构信息
Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Natural Products for Neuroprotection and Anti-Ageing Research Unit, Chulalongkorn University, Bangkok, 10330, Thailand.
出版信息
F1000Res. 2024 Dec 17;12:1265. doi: 10.12688/f1000research.141669.2. eCollection 2023.
Historically, plant derived natural products and their crude extracts have been used to treat a wide range of ailments across the world. Biogerontology research aims to explore the molecular basis of aging and discover new anti-aging therapeutic compounds or formulations to combat the detrimental effects of aging and promote a healthy life span. The budding yeast has been, and continues to be, an indispensable model organism in the field of biomedical research for discovering the molecular basis of aging has preserved nutritional signaling pathways (such as the target of rapamycin (TOR)-Sch9 and the Ras-AC-PKA (cAMP-dependent protein kinase) pathways, and shows two distinct aging paradigms chronological life span (CLS) and replicative life span (RLS). This review explores the anti-aging properties of natural products, predominantly derived from plants, and phytoextracts using as a model organism.
从历史上看，植物源天然产物及其粗提物在世界各地被用于治疗多种疾病。生物老年学研究旨在探索衰老的分子基础，并发现新的抗衰老治疗化合物或制剂，以对抗衰老的有害影响并促进健康的寿命。出芽酵母一直是并将继续是生物医学研究领域中发现衰老分子基础的不可或缺的模式生物，它保留了营养信号通路（如雷帕霉素靶蛋白（TOR）-Sch9和Ras-AC-PKA（环磷酸腺苷依赖性蛋白激酶）通路），并表现出两种不同的衰老模式：时序寿命（CLS）和复制寿命（RLS）。本综述以出芽酵母为模式生物，探讨主要来源于植物的天然产物和植物提取物的抗衰老特性。
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