and Antimicrobial Activity against Methicillin-Resistant of Essential Oils from Four Medicinal Plants in Xuan Thuy Mangrove Forest.

, , , and are medicinal plants found in Xuan Thuy mangrove forest that contain essential oils (EOs) and the potential to treat infections. The obtained yields of hydrodistillation essential oil from aerial parts and leaves ranged from 0.01% to 0.12% (v/w) on a fresh-weight basis. Subsequently, assessments indicated that the EOs of , , and displayed antibacterial effects against methicillin-resistant (MRSA), with exhibiting bactericidal effects at minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 0.2% EO, and exhibiting bacteriostatic effects with both MIC and MBC values of 0.8% EO. However, the EO of showed no inhibitory effects against , even at concentrations of up to 0.8% EO. Furthermore, docking results showed that six compounds exhibited particularly high binding energies (< -7 kcal/mol): -phellandrene, -caryophyllene, -guaiene, alloaromadendrene, bicyclosesquiphellandrene, and bicyclogermacrene. Among these, -phellandrene, -caryophyllene, bicyclosesquiphellandrene, and bicyclogermacrene are the main components in the EO; -caryophyllene, -guaiene, and alloaromadendrene are the main components in the EO; and -caryophyllene and alloaromadendrene are the main components in the EO. These findings highlight the antibacterial potential of EOs from mangrove plants; therefore, expanded investigations into EOs and the biological properties of mangrove plants may be a promising strategy for combating antimicrobial resistance.