线粒体稳态的泛素化调控：胃肠道肿瘤治疗的新视角
Ubiquitination regulation of mitochondrial homeostasis: a new sight for the treatment of gastrointestinal tumors.
作者信息
Huang Bingqian, Yang Yulin, Liu Jinming, Zhang Biao, Lin Nengming
机构信息
Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
School of Clinical Chinese Medicine, Gansu University of Chinese Medicine, Gansu, China.
出版信息
Front Immunol. 2025 Mar 11;16:1533007. doi: 10.3389/fimmu.2025.1533007. eCollection 2025.
Mitochondrial homeostasis (MH) refers to the dynamic balance of mitochondrial number, function, and quality within cells. Maintaining MH is significant in the occurrence, development, and clinical treatment of Gastrointestinal (GI) tumors. Ubiquitination, as an important post-translational modification mechanism of proteins, plays a central role in the regulation of MH. Over the past decade, research on the regulation of MH by ubiquitination has focused on mitochondrial biogenesis, mitochondrial dynamics, Mitophagy, and mitochondrial metabolism during these processes. This review summarizes the mechanism and potential therapeutic targets of ubiquitin (Ub)-regulated MH intervention in GI tumors.
线粒体稳态（MH）是指细胞内线粒体数量、功能和质量的动态平衡。维持线粒体稳态在胃肠道（GI）肿瘤的发生、发展及临床治疗中具有重要意义。泛素化作为蛋白质重要的翻译后修饰机制，在调节线粒体稳态中发挥核心作用。在过去十年中，关于泛素化对线粒体稳态调节的研究聚焦于这些过程中的线粒体生物发生、线粒体动力学、线粒体自噬及线粒体代谢。本文综述了泛素（Ub）调节的线粒体稳态干预在胃肠道肿瘤中的机制及潜在治疗靶点。
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