ESCRT 复合物。
The ESCRT complexes.
机构信息
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.
出版信息
Crit Rev Biochem Mol Biol. 2010 Dec;45(6):463-87. doi: 10.3109/10409238.2010.502516. Epub 2010 Jul 23.
Abstract
The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0, -I, -II, -III, and Vps4-Vta1, and the ALIX homodimer. The ESCRT system is required for degradation of unneeded or dangerous plasma membrane proteins; biogenesis of the lysosome and the yeast vacuole; the budding of most membrane enveloped viruses; the membrane abscission step in cytokinesis; macroautophagy; and several other processes. From their initial discovery in 2001-2002, the literature on ESCRTs has grown exponentially. This review will describe the structure and function of the six complexes noted above and summarize current knowledge of their mechanistic roles in cellular pathways and in disease.
摘要
ESCRT 机制由外周膜蛋白复合物 ESCRT-0、-I、-II、-III 和 Vps4-Vta1 以及 ALIX 同源二聚体组成。ESCRT 系统对于降解不需要或危险的质膜蛋白、溶酶体和酵母液泡的生物发生、大多数膜包裹病毒的出芽、胞质分裂中的膜分离步骤、巨自噬以及其他几个过程是必需的。自 2001-2002 年首次发现以来，ESCRTs 的文献呈指数级增长。本综述将描述上述六个复合物的结构和功能，并总结它们在细胞途径和疾病中的机制作用的最新知识。
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