空间钙剖析：解密普遍存在的胞质钙振荡
Spatial Ca profiling: decrypting the universal cytosolic Ca oscillation.
作者信息
Samanta Krishna, Parekh Anant B
机构信息
Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
出版信息
J Physiol. 2017 May 15;595(10):3053-3062. doi: 10.1113/JP272860. Epub 2016 Dec 30.
Abstract
Stimulation of cell-surface receptors that couple to phospholipase C to generate the second messenger inositol trisphosphate often evokes repetitive oscillations in cytosolic Ca . Signalling information is encoded in both the amplitude and frequency of the Ca spikes. Recent studies have revealed that the spatial profile of the oscillation also imparts signalling power; Ca microdomains near store-operated CRAC channels in the plasma membrane and inositol trisphosphate-gated channels in the endoplasmic reticulum both signal to distinct downstream targets. Spatial profiling therefore increases the transduction power of the universal oscillatory cytosolic Ca signal.
摘要
刺激与磷脂酶C偶联的细胞表面受体以生成第二信使三磷酸肌醇，常常会引发胞质钙离子的重复振荡。信号信息编码于钙离子峰的幅度和频率之中。最近的研究表明，振荡的空间分布也赋予了信号传递能力；质膜中储存操纵性钙释放激活钙通道（CRAC通道）附近以及内质网中三磷酸肌醇门控通道附近的钙离子微区均向不同的下游靶点发出信号。因此，空间分布增强了普遍存在的振荡性胞质钙离子信号的转导能力。
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